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High-sensitivity ultrasound-modulated optical tomography with a photorefractive polymer

Suzuki, Yuta and Lai, Puxiang and Xu, Xiao and Wang, Lihong (2013) High-sensitivity ultrasound-modulated optical tomography with a photorefractive polymer. Optics Letters, 38 (6). pp. 899-901. ISSN 0146-9592. PMCID PMC3626994. https://resolver.caltech.edu/CaltechAUTHORS:20160803-102318515

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Abstract

By detecting ultrasonically tagged diffuse light, ultrasound-modulated optical tomography images optical contrast with ultrasonic resolution deep in turbid media, such as biological tissue. However, small detection etendues and weak tagged light submerged in strong untagged background light limit the signal detection sensitivity. In this Letter, we report the use of a large-area (∼5 cm×5 cm ) photorefractive polymer film that yields more than 10 times detection etendue over previous detection schemes. Our polymer-based system enabled us to resolve absorbing objects embedded inside diffused media thicker than 80 transport mean free paths, by using moderate light power and short ultrasound pulses.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1364/OL.38.000899DOIArticle
https://www.osapublishing.org/ol/abstract.cfm?uri=ol-38-6-899PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626994PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong0000-0001-9783-4383
Additional Information:© 2013 Optical Society of America. Received November 26, 2012; revised January 30, 2013; accepted February 10, 2013; posted February 11, 2013 (Doc. ID 179976); published March 12, 2013. We thank Nitto Denko Technical (Oceanside, California) for providing the PRP for this research. This work was sponsored in part by National Academies Keck Futures Initiative grant IS 13 and National Institutes of Health grants DP1 EB016986 (NIH Director’s Pioneer Award), R01 EB000712, and U54 CA136398.
Funders:
Funding AgencyGrant Number
National Academies Keck Futures InitiativeIS 13
NIHDP1 EB016986
NIHR01 EB000712
NIHU54 CA136398
Issue or Number:6
Classification Code:OCIS codes: 170.3880, 170.6960, 080.2175, 190.7070
PubMed Central ID:PMC3626994
Record Number:CaltechAUTHORS:20160803-102318515
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160803-102318515
Official Citation:Yuta Suzuki, Puxiang Lai, Xiao Xu, and Lihong Wang, "High-sensitivity ultrasound-modulated optical tomography with a photorefractive polymer," Opt. Lett. 38, 899-901 (2013)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69405
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:03 Aug 2016 23:47
Last Modified:03 Oct 2019 10:21

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