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Photoacoustic and optical coherence tomography of epilepsy with high temporal and spatial resolution and dual optical contrasts

Tsytsarev, Vassiliy and Rao, Bin and Maslov, Konstantin I. and Li, Li and Wang, Lihong V. (2013) Photoacoustic and optical coherence tomography of epilepsy with high temporal and spatial resolution and dual optical contrasts. Journal of Neuroscience Methods, 216 (2). pp. 142-145. ISSN 0165-0270. PMCID PMC3695704. https://resolver.caltech.edu/CaltechAUTHORS:20160805-131858122

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Abstract

Epilepsy mapping with high spatial and temporal resolution has great significance for both fundamental research on epileptic neurons and the clinical management of epilepsy. In this communication, we demonstrate for the first time in vivo epilepsy mapping with high spatial and temporal resolution and dual optical contrasts in an animal model. Through the variations of a depthresolved optical coherence tomography signal with optical scattering contrast, we observed that epileptic neuron activities modulated the optical refractive index of epileptic neurons and their surrounding tissue. Simultaneously, through neurovasculature coupling mechanisms and optical absorption contrast, we used photoacoustic signals to document the hemodynamic changes of the microvasculature surrounding the epileptic neurons. The epilepsy mapping results were confirmed by a simultaneously recorded electroencephalogram signal during epileptic seizure. Our new epilepsy mapping tool, with high temporal and spatial resolution and dual optical contrasts, may find many applications, such as drug development and epilepsy surgery.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1016/j.jneumeth.2013.04.001DOIArticle
http://www.sciencedirect.com/science/article/pii/S0165027013001313PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3695704PubMed CentralArticle
ORCID:
AuthorORCID
Rao, Bin0000-0001-6494-3110
Maslov, Konstantin I.0000-0003-3408-8840
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2013 Elsevier B.V. Received 28 January 2013; Received in revised form 1 April 2013; Accepted 4 April 2013. This work was sponsored in part by National Institutes of Health grants R01 EB008085, R01 CA134539, U54 CA136398, R01 CA157277, R01 CA159959, DP1 EB016986 (NIH Director’s Pioneer Award). L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. K.M. has a financial interest in Microphotoacoustics, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHR01 EB008085
NIHR01 CA134539
NIHU54 CA136398
NIHR01 CA157277
NIHR01 CA159959
NIHDP1 EB016986
Subject Keywords:Photoacoustic microscopy; Optical coherence tomography; Epileptic seizures; 4-Aminopyridine
Issue or Number:2
PubMed Central ID:PMC3695704
Record Number:CaltechAUTHORS:20160805-131858122
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160805-131858122
Official Citation:Vassiliy Tsytsarev, Bin Rao, Konstantin I. Maslov, Li Li, Lihong V. Wang, Photoacoustic and optical coherence tomography of epilepsy with high temporal and spatial resolution and dual optical contrasts, Journal of Neuroscience Methods, Volume 216, Issue 2, 15 June 2013, Pages 142-145, ISSN 0165-0270, http://dx.doi.org/10.1016/j.jneumeth.2013.04.001. (http://www.sciencedirect.com/science/article/pii/S0165027013001313)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69478
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 Aug 2016 21:10
Last Modified:09 Mar 2020 13:19

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