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Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data

Huang, Chao and Nie, Liming and Schoonover, Robert W. and Guo, Zijian and Schirra, Carsten O. and Anastasio, Mark A. and Wang, Lihong V. (2012) Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data. Journal of Biomedical Optics, 17 (6). Art. No. 066016. ISSN 1083-3668. PMCID PMC3381039. https://resolver.caltech.edu/CaltechAUTHORS:20160809-101735482

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Abstract

A challenge in photoacoustic tomography (PAT) brain imaging is to compensate for aberrations in the measured photoacoustic data due to their propagation through the skull. By use of information regarding the skull morphology and composition obtained from adjunct x-ray computed tomography image data, we developed a subject-specific imaging model that accounts for such aberrations. A time-reversal-based reconstruction algorithm was employed with this model for image reconstruction. The image reconstruction methodology was evaluated in experimental studies involving phantoms and monkey heads. The results establish that our reconstruction methodology can effectively compensate for skull-induced acoustic aberrations and improve image fidelity in transcranial PAT.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/1.JBO.17.6.066016DOIArticle
http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1306224PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3381039PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2012 SPIE. Paper 12034 received Jan. 13, 2012; revised manuscript received Apr. 9, 2012; accepted for publication Apr. 12, 2012; published online Jun. 5, 2012. Chao Huang, Robert W. Schoonover, and Mark A. Anastasio acknowledge support in part by NIH awards EB010049 and EB009715. Liming Nie, Zijian Guo, and Lihong V. Wang acknowledges support by the NIH awards EB010049, CA134539, EB000712, CA136398, and EB008085. L.V.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHEB010049
NIHEB009715
NIHCA134539
NIHEB000712
NIHCA136398
NIHEB008085
Subject Keywords:diffraction; image reconstruction; photoacoustic tomography brain imaging; acoustic aberration; time reversal image reconstruction; photoacoustics; tomography
Issue or Number:6
PubMed Central ID:PMC3381039
Record Number:CaltechAUTHORS:20160809-101735482
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160809-101735482
Official Citation:Huang C, Nie L, Schoonover RW, et al; Aberration correction for transcranial photoacoustic tomography of primates employing adjunct image data. J. Biomed. Opt. 0001;17(6):066016-1-066016-8. doi:10.1117/1.JBO.17.6.066016
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69512
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Aug 2016 18:37
Last Modified:03 Oct 2019 10:22

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