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Dependence of photoacoustic speckles on boundary roughness

Guo, Zijian and Xu, Zhun and Wang, Lihong V. (2012) Dependence of photoacoustic speckles on boundary roughness. Journal of Biomedical Optics, 17 (4). Art. No. 046009. ISSN 1083-3668. PMCID PMC3380940. doi:10.1117/1.JBO.17.4.046009. https://resolver.caltech.edu/CaltechAUTHORS:20160809-104529194

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Abstract

Speckles have been considered ubiquitous in all scattering-based coherent imaging technologies. However, as an optical-absorption-based coherent imaging technology, photoacoustic (PA) tomography (PAT) suppresses speckles by building up prominent boundary signals. We theoretically study the dependence of PAT speckles on the boundary roughness, which is quantified by the root-mean-squared value and the correlation length of the boundary height. Both the speckle visibility and the correlation coefficient between the reconstructed and actual boundaries are quantified. If the root-mean-squared height fluctuation is much greater than, and the height correlation length is much smaller than the imaging resolution, the reconstructed boundaries become fully developed speckles. In other words, speckle formation requires large uncorrelated height fluctuations within the resolution cell. The first- and second-order statistics of PAT speckles are also studied experimentally. While the amplitude of the speckles follows a Gaussian distribution, the autocorrelation of the speckle patterns tracks that of the system point spread function.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/1.JBO.17.4.046009DOIArticle
http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1183119PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380940PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2012 SPIE. Paper 11724 received Dec. 7, 2011; revised manuscript received Feb. 9, 2012; accepted for publication Feb. 13, 2012; published online Apr. 19, 2012. The authors would like to thank Li Li, Yan Liu, and Alejandro Garcia-Uribe for their helpful discussions. This work has been supported in part by National Institutes of Health Grant Nos. R01 EB000712, R01 EB008085, R01 CA134539, R01 CA157277, R01 EB010049, and U54 CA136398. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA134539
NIHR01 CA157277
NIHR01 EB010049
NIHU54 CA136398
Subject Keywords:photoacoustic tomography; speckle; boundary roughness; statistics; point spread function
Issue or Number:4
PubMed Central ID:PMC3380940
DOI:10.1117/1.JBO.17.4.046009
Record Number:CaltechAUTHORS:20160809-104529194
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160809-104529194
Official Citation:Guo Z, Xu Z, Wang LV; Dependence of photoacoustic speckles on boundary roughness. J. Biomed. Opt. 0001;17(4):046009-1-046009-6. doi:10.1117/1.JBO.17.4.046009
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69514
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:09 Aug 2016 18:44
Last Modified:11 Nov 2021 04:15

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