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In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe

Wang, Yu and Erpelding, Todd N. and Jankovic, Ladislav and Guo, Zijian and Robert, Jean-Luc and David, Guillaume and Wang, Lihong V. (2012) In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe. Journal of Biomedical Optics, 17 (6). Art. No. 061208. ISSN 1083-3668. PMCID PMC3380932.

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We present an integrated photoacoustic and ultrasonic three-dimensional (3-D) volumetric imaging system based on a two-dimensional (2-D) matrix array ultrasound probe. A wavelength-tunable dye laser pumped by a Q-switched Nd:YAG laser serves as the light source and a modified commercial ultrasound imaging system (iU22, Philips Healthcare) with a 2-D array transducer (X7-2, Philips Healthcare) detects both the pulse-echo ultrasound and photoacoustic signals. A multichannel data acquisition system acquires the RF channel data. The imaging system enables rendering of co-registered 3-D ultrasound and photoacoustic images without mechanical scanning. The resolution along the azimuth, elevation, and axial direction are measured to be 0.69, 0.90 and 0.84 mm for photoacoustic imaging. In vivo 3-D photoacoustic mapping of the sentinel lymph node was demonstrated in a rat model using methylene blue dye. These results highlight the clinical potential of 3-D PA imaging for identification of sentinel lymph nodes for cancer staging in humans.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Wang, Yu0000-0003-3589-9274
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2012 SPIE. Paper 11549SSP received Sep. 30, 2011; revised manuscript received Dec. 14, 2011; accepted for publication Dec. 19, 2011.; published online May 7, 2012. The authors are grateful to Chulhong Kim and Feng Gao for beneficial discussions. They also thank Guo Li and Christopher Favazza for help with manuscript preparation. This research was supported by National Institutes of Health grants U54 CA136398 (Network for Translational Research), R01 EB000712, R01 EB008085, and R01 CA134539. LVW has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. Todd N. Erpelding, Ladislav Jankovic, and Jean-Luc Robert are employees of Philips Research.
Funding AgencyGrant Number
NIHU54 CA136398
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA134539
Subject Keywords:photoacoustic imaging; ultrasound imaging; three-dimensional imaging; sentinel lymph node
Issue or Number:6
PubMed Central ID:PMC3380932
Record Number:CaltechAUTHORS:20160810-090804039
Persistent URL:
Official Citation:Yu Wang ; Todd N. Erpelding ; Ladislav Jankovic ; Zijian Guo ; Jean-Luc Robert, et al. "In vivo three-dimensional photoacoustic imaging based on a clinical matrix array ultrasound probe", J. Biomed. Opt. 17(6), 061208 (May 07, 2012). ;
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69532
Deposited By: Tony Diaz
Deposited On:10 Aug 2016 16:50
Last Modified:09 Mar 2020 13:19

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