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Note on the Control of Gene Expression during Development

Davidson, Eric H. and Britten, Roy J. (1971) Note on the Control of Gene Expression during Development. Journal of Theoretical Biology, 32 (1). pp. 123-130. ISSN 0022-5193. doi:10.1016/0022-5193(71)90140-8.

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The process of development is interpreted in terms of a recent theory of gene regulation. In that theory agents interact with sensor structures associated with the genome. It was proposed that these interactions lead to the transcription of integrator genes and their products in turn effect control of the transcription of many genes and establish patterns of gene activation. The elements of the theory appear sufficient, in principle, to explain the process of development. We assume that there exists an initial divergence in genetic activity due to an unequal distribution of egg cytoplasmic regulatory elements among the different cells in early cleavage. As a result particular sensor structures could be synthesized in some cells and not in others. Therefore, individual cells would differ in their response to external inductive agents arising, for example, in nearby cell layers. Each specific cell or cell type would then be characterized by the integrated activation of a proper set of genes and be capable of carrying out its role in subsequent developmental events.

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Additional Information:© 1971 Elsevier Ltd. Received 30 September 1970, and in revised form 24 November 1970.
Issue or Number:1
Record Number:CaltechAUTHORS:20160811-072314286
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Official Citation:Eric H. Davidson, Roy J. Britten, Note on the control of gene expression during development, Journal of Theoretical Biology, Volume 32, Issue 1, July 1971, Pages 123-130, ISSN 0022-5193, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69559
Deposited By: Ruth Sustaita
Deposited On:11 Aug 2016 17:09
Last Modified:11 Nov 2021 04:16

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