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Multiple Length DNA Molecules of Bacteriophage φX174

Benbow, R. M. and Eisenberg, M. and Sinsheimer, R. L. (1972) Multiple Length DNA Molecules of Bacteriophage φX174. Nature New Biology, 237 (74). pp. 141-144. ISSN 0369-4887. doi:10.1038/newbio237141a0.

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RUSH and Warner have suggested that circular double length DNA molecules1–3 of bacteriophage S13 arise during genetic recombination, presumably in a single reciprocal recombination event4–6 between two monomeric circles7. In other systems, however, circular molecules of multiple length are produced by errors in replication8,9. We now demonstrate that most circular multiple length DNA molecules of bacteriophage φX174 arise by replication and that, moreover, some catenated DNA molecules contain interlocked rings of two different parental types.

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Additional Information:© 1972 Nature Publishing Group. Received December 6, 1971; revised February 14, 1972. We thank Drs Paul Howard-Flanders and Philip Sharp for suggestions and Mrs J. S. Kim for the plates in Fig. 2. This research was supported by a grant from the US Public Health Service. R. B. is supported by a National Institutes of Health training grant, and M. E. by a fellowship from the Rockefeller Foundation.
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U.S. Public Health Service (USPHS)UNSPECIFIED
NIH Predoctoral FellowshipUNSPECIFIED
Rockefeller FoundationUNSPECIFIED
Issue or Number:74
Record Number:CaltechAUTHORS:20160812-122302614
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69596
Deposited By: Ruth Sustaita
Deposited On:12 Aug 2016 22:40
Last Modified:11 Nov 2021 04:16

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