Davidson, Eric H. and Britten, Roy J. (1974) Molecular Aspects of Gene Regulation in Animal Cells. Cancer Research, 34 (8). pp. 2034-2043. ISSN 0008-5472. https://resolver.caltech.edu/CaltechAUTHORS:20160812-123233378
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Abstract
Gene regulation in animal cells may occur at several stages of RNA metabolism, including synthesis, processing, transport, and utilization of the RNA. This discussion primarily concerns transcription level regulation, i.e., control over which sequences in the genomic DNA are transcribed. Current evidence indicates that this is the initial level of regulation in the differentiated animal cell; this conclusion is supported by quantitative hybridization experiments as well as by other kinds of data. Recent experiments are considered which show that animal structural genes are in general DNA sequences occurring only once per haploid genome. For at least one system, the sea urchin embryo, the amount of nonrepetitive DNA sequence represented in the mRNA's is known. About 14,000 average-sized structural genes are represented in the polysomal mRNA of this 600-cell embryo. Studies on organization of DNA sequences show that at least 80% of the DNA of Xenopus and sea urchin consists of short (300 nucleotides) repetitive sequence elements interspersed with longer nonrepetitive sequence regions. This arrangement is an ordered one, suggesting selective value in evolution and therefore function. Such a sequence arrangement pattern could account for the system properties of gene regulation in animal cells.
Item Type: | Article | ||||||
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Additional Information: | © 1974 American Association for Cancer. Presented at the Third Conference on Embryonic and Fetal Antigens in Cancer, November 4 to 7, 1973, Knoxville, Tenn. Supported by Grants USPHS HD-05753 and National Science Foundation GB-33441. | ||||||
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Issue or Number: | 8 | ||||||
Record Number: | CaltechAUTHORS:20160812-123233378 | ||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160812-123233378 | ||||||
Official Citation: | Molecular Aspects of Gene Regulation in Animal Cells Eric H. Davidson, Roy J. Britten Cancer Res Aug 1974 (34) (8) 2034-2043 | ||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | ||||||
ID Code: | 69597 | ||||||
Collection: | CaltechAUTHORS | ||||||
Deposited By: | Ruth Sustaita | ||||||
Deposited On: | 12 Aug 2016 22:37 | ||||||
Last Modified: | 03 Oct 2019 10:23 |
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