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Performance characterization of an integrated ultrasound, photoacoustic, and thermoacoustic imaging system

Ke, Haixin and Erpelding, Todd N. and Jankovic, Ladislav and Liu, Changjun and Wang, Lihong V. (2012) Performance characterization of an integrated ultrasound, photoacoustic, and thermoacoustic imaging system. Journal of Biomedical Optics, 17 (5). Art. No. 056010. ISSN 1083-3668. PMCID PMC3381021.

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We developed a novel trimodality system for human breast imaging by integrating photoacoustic (PA) and thermoacoustic (TA) imaging techniques into a modified commercial ultrasound scanner. Because light was delivered with an optical assembly placed within the microwave antenna, no mechanical switching between the microwave and laser sources was needed. Laser and microwave excitation pulses were interleaved to enable PA and TA data acquisition in parallel at a rate of 10 frames per second. A tube (7 mm inner diameter) filled with oxygenated bovine blood or 30 mM methylene blue dye was successfully detected in PA images in chicken breast tissue at depths of 6.6 and 8.4 cm, respectively, for the first time. The SNRs at these depths reached ∼24 and ∼15  dB, respectively, by averaging 200 signal acquisitions. Similarly, a tube (13 mm inner diameter) filled with saline solution (0.9%) at a depth of 4.4 cm in porcine fat tissue was successfully detected in TA images. The PA axial, lateral, and elevational resolutions were 640 μm, 720 μm, and 3.5 mm, respectively, suitable for breast cancer imaging. A PA noise-equivalent sensitivity to methylene blue solution of 260 nM was achieved in chicken tissue at a depth of 3.4 cm.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Liu, Changjun0000-0003-0079-6793
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2012 SPIE. Paper 11739 received Dec. 19, 2011; revised manuscript received Mar. 28, 2012; accepted for publication Mar. 29, 2012; published online May 4, 2012. We acknowledge John Dean, Viktor Gornstein, and Ramon Erkamp from Philips Research North America for their help with building the system. This work was sponsored in part by National Institutes of Health grants R01 CA134539, U54 CA136398, R01 EB000712, R01 EB008085, R01 EB010049, and R01 CA157277. L.V.W. has a financial interest in Microphotoacoustics, Inc., and in Endra, Inc., which, however, did not support this work.
Funding AgencyGrant Number
NIHR01 CA134539
NIHU54 CA136398
NIHR01 EB000712
NIHR01 EB008085
NIHR01 EB010049
NIHR01 CA157277
Subject Keywords:photoacoustic tomography; thermoacoustic tomography; ultrasound imaging
Issue or Number:5
PubMed Central ID:PMC3381021
Record Number:CaltechAUTHORS:20160812-142854532
Persistent URL:
Official Citation:Ke H, Erpelding TN, Jankovic L, Liu C, Wang LV; Performance characterization of an integrated ultrasound, photoacoustic, and thermoacoustic imaging system. J. Biomed. Opt. 0001;17(5):056010-1-056010-6. doi:10.1117/1.JBO.17.5.056010
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69604
Deposited By: Tony Diaz
Deposited On:12 Aug 2016 22:19
Last Modified:09 Mar 2020 13:19

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