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Photoacoustic Sentinel Lymph Node Imaging with Self-Assembled Copper Neodecanoate Nanoparticles

Pan, Dipanjan and Cai, Xin and Yalaz, Ceren and Senpan, Angana and Omanakuttan, Karthik and Wickline, Samuel A. and Wang, Lihong V. and Lanza, Gregory M. (2012) Photoacoustic Sentinel Lymph Node Imaging with Self-Assembled Copper Neodecanoate Nanoparticles. ACS Nano, 6 (2). pp. 1260-1267. ISSN 1936-0851. PMCID PMC3289744.

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Photoacoustic tomography (PAT) is emerging as a novel, hybrid, and non-ionizing imaging modality because of its satisfactory spatial resolution and high soft tissue contrast. PAT combines the advantages of both optical and ultrasonic imaging methods. It opens up the possibilities for noninvasive staging of breast cancer and may replace sentinel lymph node (SLN) biopsy in clinic in the near future. In this work, we demonstrate for the first time that copper can be used as a contrast metal for near-infrared detection of SLN using PAT. A unique strategy is adopted to encapsulate multiple copies of Cu as organically soluble small molecule complexes within a phospholipid-entrapped nanoparticle. The nanoparticles assumed a size of 80–90 nm, which is the optimum hydrodynamic diameter for its distribution throughout the lymphatic systems. These particles provided at least 6-fold higher signal sensitivity in comparison to blood, which is a natural absorber of light. We also demonstrated that high SLN detection sensitivity with PAT can be achieved in a rodent model. This work clearly demonstrates for the first time the potential use of copper as an optical contrast agent.

Item Type:Article
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URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2012 American Chemical Society. Publication Date (Web): January 09, 2012. This research was supported by grants from the AHA (0835426N and 11IRG5690011), NIH (R01CA154737), NCI (U54CA119342), BRP (HL073646), and the NHLBI (R01HL073646, R01HL078631). We thank Mr. Allen J. Stacy for help with the biodistribution experiment. We also thank Ms. Marilyn Levy (Cell Biology) and Ms. Kate Nelson (Nano Research Facility, Washington University in St. Louis) for helping us with TEM and EDX experiments, respectively.
Funding AgencyGrant Number
American Heart Association0835426N
American Heart Association11IRG5690011
National Cancer InstituteU54CA119342
Subject Keywords:copper; nanoparticle; optical imaging; contrast agent; photoacoustic imaging; sentinel lymph node; breast cancer staging
Issue or Number:2
PubMed Central ID:PMC3289744
Record Number:CaltechAUTHORS:20160812-151338825
Persistent URL:
Official Citation:Photoacoustic Sentinel Lymph Node Imaging with Self-Assembled Copper Neodecanoate Nanoparticles Dipanjan Pan, Xin Cai, Ceren Yalaz, Angana Senpan, Karthik Omanakuttan, Samuel A. Wickline, Lihong V. Wang, and Gregory M. Lanza ACS Nano 2012 6 (2), 1260-1267 DOI: 10.1021/nn203895n
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69611
Deposited By: Tony Diaz
Deposited On:12 Aug 2016 22:22
Last Modified:03 Oct 2019 10:23

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