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Photoacoustic tomography through a whole adult human skull with a photon recycler

Nie, Liming and Cai, Xin and Maslov, Konstantin and Garcia-Uribe, Alejandro and Anastasio, Mark A. and Wang, Lihong V. (2012) Photoacoustic tomography through a whole adult human skull with a photon recycler. Journal of Biomedical Optics, 17 (11). Art. No. 110506. ISSN 1083-3668. PMCID PMC3487537.

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Photoacoustic tomography (PAT) of the human brain is challenging due to the fact that the skull strongly absorbs and scatters light, and attenuates and distorts ultrasound as well. For the first time, we demonstrated the feasibility of PAT through a whole adult human skull. A photon recycler (PR) was built to increase light transmittance through the skull. Both a graphite target and a canine brain were imaged through the skull. Use of the PR was found to improve the photoacoustic signal-to-noise ratio by a factor of 2.4. In addition, subtraction of photoacoustic signals that arise from light absorption within the skull significantly improved the contrast of the target. Our results indicate that PAT can potentially be applied to in vivo human brain imaging.

Item Type:Article
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URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2012 SPIE. Paper 12630L received Sep. 22, 2012; revised manuscript received Oct. 16, 2012; accepted for publication Oct. 17, 2012; published online Nov. 2, 2012. We thank Ms. Sandra Matteucci for the close manuscript proofreading. We acknowledge support by the NIH awards R01 EB010049, R01 CA134539, R01 EB000712, U54 CA136398, and R01 EB008085. L. V. W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funding AgencyGrant Number
NIHR01 EB010049
NIHR01 CA134539
NIHR01 EB000712
NIHU54 CA136398
NIHR01 EB008085
Subject Keywords:human brain imaging; photoacoustic tomography; optical scattering; skull absorption; subtraction imaging; transcranial imaging
Issue or Number:11
PubMed Central ID:PMC3487537
Record Number:CaltechAUTHORS:20160812-153536809
Persistent URL:
Official Citation:Nie L, Cai X, Maslov K, Garcia-Uribe A, Anastasio MA, Wang LV; Photoacoustic tomography through a whole adult human skull with a photon recycler. J. Biomed. Opt. 0001;17(11):110506-110506. doi:10.1117/1.JBO.17.11.110506
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69612
Deposited By: Tony Diaz
Deposited On:12 Aug 2016 23:11
Last Modified:03 Oct 2019 10:23

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