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Transcriptional Regulation of T Cell Lineage Commitment

Rothenberg, Ellen V. (2016) Transcriptional Regulation of T Cell Lineage Commitment. In: Encyclopedia of Immunobiology. Vol.1. Elsevier , Amsterdam, pp. 201-210. ISBN 978-0-08-092152-5.

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Through most of life, multilineage precursor cells undergo commitment to the T cell lineage only after immigrating to the thymus. These cells undergo a stepwise process through which they give up potential to become B cells, myeloid cells, dendritic cells, natural killer cells, or innate lymphoid cells. The commitment process involves separate mechanisms to deal with each of these options, with environmental Notch signaling deferring access to the alternative pathways through multiple rounds of cell division until permanent, intrinsic mechanisms of alternative fate exclusion can be established. The basis for measuring alternative lineage potential, the roles of environmental signals in promoting different fates, the transcriptional machinery that provides access to them, and the T cell–specific factors that eventually eliminate them are described in this article.

Item Type:Book Section
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Rothenberg, Ellen V.0000-0002-3901-347X
Additional Information:© 2016 Elsevier Ltd. Available online 9 May 2016.
Subject Keywords:Bcl11b; C/EBPα; Developmental potential; EBF1; Fate determination; GATA-3; Hes1; Nfil3; Notch signaling; PU.1; T cell development; Transcription factors
Record Number:CaltechAUTHORS:20160816-095349032
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Official Citation:Ellen V. Rothenberg, Transcriptional Regulation of T Cell Lineage Commitment, In Encyclopedia of Immunobiology, edited by Michael J.H. Ratcliffe,, Academic Press, Oxford, 2016, Pages 201-210, ISBN 9780080921525, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69651
Deposited By: Tony Diaz
Deposited On:16 Aug 2016 17:18
Last Modified:11 Nov 2021 04:17

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