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Seeing it through: translational validation of new medical imaging modalities

Aldrich, Melissa B. and Marshall, Milton V. and Sevick-Muraca, Eva M. and Lanza, Greg and Kotyk, John and Culver, Joseph and Wang, Lihong V. and Uddin, Jashim and Crews, Brenda C. and Marnett, Lawrence J. and Liao, Joseph C. and Contag, Chris and Crawford, James M. and Wang, Ken and Reisdorph, Bill and Appelman, Henry and Turgeon, D. Kim and Meyer, Charles and Wang, Tom (2012) Seeing it through: translational validation of new medical imaging modalities. Biomedical Optics Express, 3 (4). pp. 764-776. ISSN 2156-7085. PMCID PMC3345805.

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Medical imaging is an invaluable tool for diagnosis, surgical guidance, and assessment of treatment efficacy. The Network for Translational Research (NTR) for Optical Imaging consists of four research groups working to “bridge the gap” between lab discovery and clinical use of fluorescence- and photoacoustic-based imaging devices used with imaging biomarkers. While the groups are using different modalities, all the groups face similar challenges when attempting to validate these systems for FDA approval and, ultimately, clinical use. Validation steps taken, as well as future needs, are described here. The group hopes to provide translational validation guidance for itself, as well as other researchers.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2012 Optical Society of America. Received 21 Dec 2011; revised 10 Feb 2012; accepted 13 Feb 2012; published 22 Mar 2012. We would like to acknowledge funding from the National Institutes of Health (NIH) U54 CA136429.
Funding AgencyGrant Number
NIHU54 CA136429
Issue or Number:4
Classification Code:OCIS codes: (170.0110) Imaging systems; (170.3880) Medical and biological imaging
PubMed Central ID:PMC3345805
Record Number:CaltechAUTHORS:20160816-103408103
Persistent URL:
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69659
Deposited By: Tony Diaz
Deposited On:16 Aug 2016 17:53
Last Modified:03 Oct 2019 10:24

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