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Helix-to-coil transitions in proteins: Helicity resonance in ultrafast electron diffraction

Lin, Milo M. and Shorokhov, Dmitry and Zewail, Ahmed H. (2006) Helix-to-coil transitions in proteins: Helicity resonance in ultrafast electron diffraction. Chemical Physics Letters, 420 (1-3). pp. 1-7. ISSN 0009-2614. doi:10.1016/j.cplett.2005.11.088.

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In this Letter, we report on the direct mapping of helicity in the helix-to-coil structural transitions by theoretically simulating the ultrafast electron diffraction (UED) technique for isolated proteins with thousands of possible conformations. A novel approach for producing random coil structures of a given helical protein is presented with proper account of the steric avoidance threshold. A ‘resonance’ is manifested in the UED patterns of the helical structures. This resonance erodes as the transition to random coils becomes dominant, indicating that the residual helicity in the sample and the ensemble-averaged radius of gyration can be obtained and related to structural dynamics of isolated proteins.

Item Type:Article
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Lin, Milo M.0000-0001-8680-2685
Additional Information:© 2005 Elsevier B.V. Received 10 November 2005; in final form 24 November 2005. Available online 27 December 2005. This work was supported by a grant from the National Science Foundation and Moore Center for Ultrafast Science and Technology. We would like to acknowledge Dr. S.T. Park for stimulating discussions.
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Gordon and Betty Moore FoundationUNSPECIFIED
Issue or Number:1-3
Record Number:CaltechAUTHORS:20160816-145536036
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Official Citation:Milo M. Lin, Dmitry Shorokhov, Ahmed H. Zewail, Helix-to-coil transitions in proteins: Helicity resonance in ultrafast electron diffraction, Chemical Physics Letters, Volume 420, Issues 1–3, 10 March 2006, Pages 1-7, ISSN 0009-2614, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69679
Deposited By: Ruth Sustaita
Deposited On:23 Aug 2016 18:25
Last Modified:11 Nov 2021 04:18

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