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Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography

Chatni, Muhammad Rameez and Xia, Jun and Sohn, Rebecca and Maslov, Konstantin and Guo, Zijian and Zhang, Yu and Wang, Kun and Xia, Younan and Anastasio, Mark and Arbeit, Jeffrey and Wang, Lihong V. (2012) Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography. Journal of Biomedical Optics, 17 (7). Art. No. 076012. ISSN 1083-3668. PMCID PMC3390466. http://resolver.caltech.edu/CaltechAUTHORS:20160816-160335773

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Abstract

With the increasing use of small animals for human disease studies, small-animal whole-body molecular imaging plays an important role in biomedical research. Currently, none of the existing imaging modalities can provide both anatomical and glucose molecular information, leading to higher costs of building dual-modality systems. Even with image co-registration, the spatial resolution of the molecular imaging modality is not improved. Utilizing a ring-shaped confocal photoacoustic computed tomography system, we demonstrate, for the first time, that both anatomy and glucose uptake can be imaged in a single modality. Anatomy was imaged with the endogenous hemoglobin contrast, and glucose metabolism was imaged with a near-infrared dye-labeled 2-deoxyglucose.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/1.JBO.17.7.076012DOIArticle
http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1352511PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3390466PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2012 SPIE. Paper 12179 received Mar. 15, 2012; revised manuscript received Jun. 4, 2012; accepted for publication Jun. 6, 2012; published online Jul. 6, 2012. The authors appreciate Ms. Seema Dahlheimer’s and Jim Ballard’s close reading of the manuscript. This work was sponsored in part by National Institutes of Health grants R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 EB010049, R01 CA157277, and R01 CA159959. L. Wang has financial interests in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA134539
NIHU54 CA136398
NIHR01 EB010049
NIHR01 CA157277
NIHR01 CA159959
Subject Keywords:acousto-optics; image analysis; photoacoustic spectroscopy
PubMed Central ID:PMC3390466
Record Number:CaltechAUTHORS:20160816-160335773
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160816-160335773
Official Citation:Chatni M, Xia J, Sohn R, et al; Tumor glucose metabolism imaged in vivo in small animals with whole-body photoacoustic computed tomography. J. Biomed. Opt. 0001;17(7):076012-1-076012-7. doi:10.1117/1.JBO.17.7.076012
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69684
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:16 Aug 2016 23:37
Last Modified:19 Sep 2018 18:24

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