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Ultrasound-modulated optical tomography at new depth

Lai, Puxiang and Xu, Xiao and Wang, Lihong V. (2012) Ultrasound-modulated optical tomography at new depth. Journal of Biomedical Optics, 17 (6). Art. No. 066006. ISSN 1083-3668. PMCID PMC3381033.

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Ultrasound-modulated optical tomography (UOT) has the potential to reveal optical contrast deep inside soft biological tissues at an ultrasonically determined spatial resolution. The optical imaging depth reported so far has, however, been limited, which prevents this technique from broader applications. Our latest experimental exploration has pushed UOT to an unprecedented imaging depth. We developed and optimized a UOT system employing a photorefractive crystal-based interferometer. A large aperture optical fiber bundle was used to enhance the efficiencies for diffuse light collection and photorefractive two-wave-mixing. Within the safety limits for both laser illumination and ultrasound modulation, the system has attained the ability to image through a tissue-mimicking phantom of 9.4 cm in thickness, which has never been reached previously by UOT.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2012 SPIE. Paper 12163 received Mar. 7, 2012; revised manuscript received Apr. 6, 2012; accepted for publication Apr. 10, 2012; published online Jun. 4, 2012. The authors thank Sandra Matteucci for editing the manuscript. This research is sponsored in part by National Academies Keck Futures Initiative grant IS 13 and National Institute of Health grants R01 EB000712 and U54 CA136398. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funding AgencyGrant Number
National Academies Keck Futures InitiativeIS 13
NIHR01 EB000712
NIHU54 CA136398
Subject Keywords:optical imaging; ultrasound-modulated optical tomography; acousto-optic imaging; ultrasound modulation; fiber bundle; light guide; photorefractive crystal; two-wave-mixing; tissue-mimicking phantom
Issue or Number:6
PubMed Central ID:PMC3381033
Record Number:CaltechAUTHORS:20160817-073054013
Persistent URL:
Official Citation:Lai P, Xu X, Wang LV; Ultrasound-modulated optical tomography at new depth. J. Biomed. Opt. 0001;17(6):066006-1-066006-6. doi:10.1117/1.JBO.17.6.066006
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69685
Deposited By: Tony Diaz
Deposited On:17 Aug 2016 18:15
Last Modified:03 Oct 2019 10:24

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