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Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo

Xia, Jun and Chatni, Muhammad R. and Maslov, Konstantin and Guo, Zijian and Wang, Kun and Anastasio, Mark and Wang, Lihong V. (2012) Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo. Journal of Biomedical Optics, 17 (5). Art. no. 050506. ISSN 1083-3668. PMCID PMC3382342. https://resolver.caltech.edu/CaltechAUTHORS:20160817-081407589

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Abstract

We report a novel small-animal whole-body imaging system called ring-shaped confocal photoacoustic computed tomography (RC-PACT). RC-PACT is based on a confocal design of free-space ring-shaped light illumination and 512-element full-ring ultrasonic array signal detection. The free-space light illumination maximizes the light delivery efficiency, and the full-ring signal detection ensures a full two-dimensional view aperture for accurate image reconstruction. Using cylindrically focused array elements, RC-PACT can image a thin cross section with 0.10 to 0.25 mm in-plane resolutions and 1.6 s/frame acquisition time. By translating the mouse along the elevational direction, RC-PACT provides a series of cross-sectional images of the brain, liver, kidneys, and bladder.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/1.JBO.17.5.050506DOIArticle
http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1183141PublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382342PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2012 SPIE. Paper 12080L received Feb. 6, 2012; revised manuscript received Apr. 4, 2012; accepted for publication Apr. 12, 2012; published online May 4, 2012. The authors appreciate Ms. Seema Dahlheimer’s close reading of the manuscript. This work was sponsored in part by National Institutes of Health grants R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 EB010049, R01 CA157277, and R01 CA159959. L. W. has financial interests in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA134539
NIHU54 CA136398
NIHR01 EB010049
NIHR01 CA157277
NIHR01 CA159959
Subject Keywords:photoacoustic computed tomography; small-animal imaging; half-time image reconstruction; anatomic imaging
Issue or Number:5
PubMed Central ID:PMC3382342
Record Number:CaltechAUTHORS:20160817-081407589
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160817-081407589
Official Citation:Xia J, Chatni MR, Maslov K, et al; Whole-body ring-shaped confocal photoacoustic computed tomography of small animals in vivo. J. Biomed. Opt. 0001;17(5):050506-1-050506-3. doi:10.1117/1.JBO.17.5.050506
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69687
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:17 Aug 2016 18:48
Last Modified:03 Oct 2019 10:24

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