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A New Theranostic System Based on Gold Nanocages and Phase-Change Materials with Unique Features for Photoacoustic Imaging and Controlled Release

Moon, Geon Dae and Choi, Sung-Wook and Cai, Xin and Li, Weiyang and Cho, Eun Chul and Jeong, Unyong and Wang, Lihong V. and Xia, Younan (2011) A New Theranostic System Based on Gold Nanocages and Phase-Change Materials with Unique Features for Photoacoustic Imaging and Controlled Release. Journal of the American Chemical Society, 133 (13). pp. 4762-4765. ISSN 0002-7863. PMCID PMC3073071. http://resolver.caltech.edu/CaltechAUTHORS:20160817-085636784

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Abstract

This communication reports a new theranostic system with a combination of capabilities to both enhance the contrast of photoacoustic (PA) imaging and control the release of a chemical or biological effector by high-intensity focused ultrasound (HIFU). The fabrication of this system simply involves filling the hollow interiors of gold nanocages with a phase-change material (PCM) such as 1-tetradecanol that has a melting point of 38−39 °C. The PCM can be premixed and thus loaded with a dye, as well as other chemical or biological effectors. When exposed to direct heating or HIFU, the PCM will melt and escape from the interiors of nanocages through small pores on the surface, concurrently releasing the encapsulated molecules into the surrounding medium. We can control the release profile by varying the power of HIFU, the duration of exposure to HIFU, or both.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/ja200894uDOIArticle
http://pubs.acs.org/doi/abs/10.1021/ja200894uPublisherArticle
http://pubs.acs.org/doi/suppl/10.1021/ja200894uPublisherSupporting Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3073071PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2011 American Chemical Society. Received: January 28, 2011; Published: March 14, 2011. This work was supported in part by a 2006 NIH Director’s Pioneer Award (DP1 OD000798), startup funds from Washington University in St. Louis, and the World Class University (WCU) program at Yonsei University. Part of the work was done at the Nano Research Facility (NRF), a member of the National Nanotechnology Infrastructure Network (NINN), which is supported by the NSF under award no. ECS-0335765.
Funders:
Funding AgencyGrant Number
NIHDP1 OD000798
Washington UniversityUNSPECIFIED
Yonsei UniversityUNSPECIFIED
NSFECS-0335765
PubMed Central ID:PMC3073071
Record Number:CaltechAUTHORS:20160817-085636784
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160817-085636784
Official Citation:A New Theranostic System Based on Gold Nanocages and Phase-Change Materials with Unique Features for Photoacoustic Imaging and Controlled Release Geon Dae Moon, Sung-Wook Choi, Xin Cai, Weiyang Li, Eun Chul Cho, Unyong Jeong, Lihong V. Wang, and Younan Xia Journal of the American Chemical Society 2011 133 (13), 4762-4765 DOI: 10.1021/ja200894u
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69689
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:17 Aug 2016 18:38
Last Modified:17 Aug 2016 18:38

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