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High-Transmission-Efficiency and Side-Viewing Micro OIDRS Probe for Fast and Minimally Invasive Tumor Margin Detection

Garcia-Uribe, Alejandro and Chang, Cheng-Chung and Yapici, Murat Kaya and Zou, Jun and Banerjee, Bhaskar and Kuczynski, John and Ong, Evan S. and Marner, Erin S. and Wang, Lihong V. (2011) High-Transmission-Efficiency and Side-Viewing Micro OIDRS Probe for Fast and Minimally Invasive Tumor Margin Detection. IEEE Sensors Journal, 11 (4). pp. 891-896. ISSN 1530-437X. PMCID PMC3072170. https://resolver.caltech.edu/CaltechAUTHORS:20160817-104828903

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Abstract

The determination of a cancer free margin I organ is a difficult and time consuming process, with an unmet need for rapid determination of tumor margin at surgery. In this paper, we report the design, fabrication, and testing of a novel miniaturized optical sensor probe with “side-viewing” capability. Its unprecedented small size, unique “side-viewing” capability, and high optical transmission efficiency enable the agile maneuvering and efficient data collection even in the narrow cavities inside the human body. The sensor probe consists of four micromachined substrates with optical fibers for oblique light incidence and collection of spatially resolved diffuse reflectance from the contacted tissues. The optical sensor probe has been used to conduct the oblique incidence diffuse reflectance spectroscopy (OIDRS) on a human pancreatic specimen. Based on the measurement results, the margin of the malignant tumor has been successfully determined optically, which matches well with the histological results.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1109/JSEN.2010.2076279DOIArticle
http://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=5585661PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3072170PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2010 IEEE. Manuscript received April 26, 2010; revised July 05, 2010; accepted August 20, 2010. Date of publication September 27, 2010; date of current version February 04, 2011. This work was supported by the National Institute of Health under Grant R01 CA106728. The associate editor coordinating the review of this paper and approving it for publication was Prof. Okyay Kaynak.
Funders:
Funding AgencyGrant Number
NIHR01 CA106728
Issue or Number:4
PubMed Central ID:PMC3072170
Record Number:CaltechAUTHORS:20160817-104828903
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160817-104828903
Official Citation:A. Garcia-Uribe et al., "High-Transmission-Efficiency and Side-Viewing Micro OIDRS Probe for Fast and Minimally Invasive Tumor Margin Detection," in IEEE Sensors Journal, vol. 11, no. 4, pp. 891-896, April 2011. doi: 10.1109/JSEN.2010.2076279
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69706
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:17 Aug 2016 18:18
Last Modified:03 Oct 2019 10:24

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