Zhao, Liang and Pal, Samir Kumar and Xia, Tianbing and Zewail, Ahmed H. (2004) Dynamics of Ordered Water in Interfacial Enzyme Recognition: Bovine Pancreatic Phospholipase A2. Angewandte Chemie International Edition, 43 (1). pp. 60-63. ISSN 1433-7851. doi:10.1002/anie.200352961. https://resolver.caltech.edu/CaltechAUTHORS:20160817-132621558
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Abstract
Slippery when wet: Water molecules at the interface between a protein (e.g. bovine pancreatic phospholipase A2) and a micellar substrate act as a lubricant and facilitate movement and binding of the protein at the surface (see picture). Studies of the hydration dynamics before and after complexation reveal that these interactions are crucial for enzymatic function.
Item Type: | Article | |||||||||
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Additional Information: | © 2004 Wiley-VCH Verlag GmbH & Co. Received: September 26, 2003. Published Online: December 8 Dec 2003. Financial support from the National Science Foundation is acknowledged. | |||||||||
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Subject Keywords: | enzymes; femtochemistry; hydration dynamics; lipases; surfactants | |||||||||
Issue or Number: | 1 | |||||||||
DOI: | 10.1002/anie.200352961 | |||||||||
Record Number: | CaltechAUTHORS:20160817-132621558 | |||||||||
Persistent URL: | https://resolver.caltech.edu/CaltechAUTHORS:20160817-132621558 | |||||||||
Official Citation: | Zhao, L., Pal, S. K., Xia, T. and Zewail, A. H. (2004), Dynamics of Ordered Water in Interfacial Enzyme Recognition: Bovine Pancreatic Phospholipase A2. Angew. Chem. Int. Ed., 43: 60–63. doi: 10.1002/anie.200352961 | |||||||||
Usage Policy: | No commercial reproduction, distribution, display or performance rights in this work are provided. | |||||||||
ID Code: | 69713 | |||||||||
Collection: | CaltechAUTHORS | |||||||||
Deposited By: | Ruth Sustaita | |||||||||
Deposited On: | 17 Aug 2016 21:43 | |||||||||
Last Modified: | 11 Nov 2021 04:18 |
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