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In vivo photoacoustic tomography of mouse cerebral edema induced by cold injury

Xu, Zhun and Zhu, Quing and Wang, Lihong V. (2011) In vivo photoacoustic tomography of mouse cerebral edema induced by cold injury. Journal of Biomedical Optics, 16 (6). Art. No. 066020. ISSN 1083-3668. PMCID PMC3124533.

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For the first time, we have implemented photoacoustic tomography (PAT) to image the water content of an edema in vivo. We produced and imaged a cold-induced cerebral edema transcranially, then obtained blood vessel and water accumulation images at 610 and 975 nm, respectively. We tracked the changes at 12, 24, and 36 h after the cold injury. The blood volume decreased after the cold injury, and the maximum area of edema was observed 24 h after the cold injury. We validated PAT of the water content of the edema through magnetic Resonance Imaging and the water spectrum from the spectrophotometric measurement.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2011 SPIE. Paper 11073LRR received Feb. 16, 2011; revised manuscript received Apr. 9, 2011; accepted for publication Apr. 12, 2011; published online Jun. 1, 2011. This work was sponsored in part by National Institutes of Health Grant Nos. R01 EB000712, R01 EB008085, R01 CA134539, U54 CA136398, R01 EB010049, and 5P60 DK02057933. L.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA134539
NIHU54 CA136398
NIHR01 EB010049
NIH5P60 DK02057933
Subject Keywords:photoacoustic tomography; cerebral edema; water imaging
Issue or Number:6
PubMed Central ID:PMC3124533
Record Number:CaltechAUTHORS:20160817-140443955
Persistent URL:
Official Citation:Xu Z, Zhu Q, Wang LV; In vivo photoacoustic tomography of mouse cerebral edema induced by cold injury. J. Biomed. Opt. 0001;16(6):066020-066020-4. doi:10.1117/1.3584847
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69720
Deposited By: Tony Diaz
Deposited On:17 Aug 2016 21:34
Last Modified:03 Oct 2019 10:24

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