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DNA/RNA nucleotides and nucleosides: direct measurement of excited-state lifetimes by femtosecond fluorescence up-conversion

Peon, Jorge and Zewail, Ahmed H. (2001) DNA/RNA nucleotides and nucleosides: direct measurement of excited-state lifetimes by femtosecond fluorescence up-conversion. Chemical Physics Letters, 348 (3-4). pp. 255-262. ISSN 0009-2614. https://resolver.caltech.edu/CaltechAUTHORS:20160818-103816734

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Abstract

Fluorescence decay times of the nucleosides: adenosine, guanosine, cytidine and thymidine, and of the corresponding nucleotides, were determined using the technique of fluorescence up-conversion with femtosecond time resolution. The excited-state lifetimes of these nucleic acid molecules all fall in the sub-picosecond time scale, confirming the presence of an ultrafast internal conversion channel for both the nucleotides and the nucleosides; the nucleotides lifetimes are longer than those of the nucleosides by up to 20%. The ultrafast internal conversion is biologically relevant to the stability of DNA, and our results support the sub-picosecond repopulation of the ground state, consistent with transient absorption studies on the femtosecond time scale.


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http://dx.doi.org/10.1016/S0009-2614(01)01128-9DOIArticle
http://www.sciencedirect.com/science/article/pii/S0009261401011289PublisherArticle
Additional Information:© 2001 Elsevier B.V. Received 20 August 2001, Available online 17 October 2001. This work was supported by a grant from the National Science Foundation. We wish to thank Dr. Dongping Zhong for his help with the initial setup of the experiments.
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Issue or Number:3-4
Record Number:CaltechAUTHORS:20160818-103816734
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160818-103816734
Official Citation:Jorge Peon, Ahmed H Zewail, DNA/RNA nucleotides and nucleosides: direct measurement of excited-state lifetimes by femtosecond fluorescence up-conversion, Chemical Physics Letters, Volume 348, Issues 3–4, 9 November 2001, Pages 255-262, ISSN 0009-2614, http://dx.doi.org/10.1016/S0009-2614(01)01128-9. (http://www.sciencedirect.com/science/article/pii/S0009261401011289)
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ID Code:69757
Collection:CaltechAUTHORS
Deposited By: Ruth Sustaita
Deposited On:18 Aug 2016 19:03
Last Modified:03 Oct 2019 10:25

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