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An Integrated Microfabricated Cell Sorter

Fu, Anne Y. and Chou, Hou-Pu and Spence, Charles and Arnold, Frances H. and Quake, Stephen R. (2002) An Integrated Microfabricated Cell Sorter. Analytical Chemistry, 74 (11). pp. 2451-2457. ISSN 0003-2700. doi:10.1021/ac0255330.

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We have developed an integrated microfabricated cell sorter using multilayer soft lithography. This integrated cell sorter is incorporated with various microfluidic functionalities, including peristaltic pumps, dampers, switch valves, and input and output wells, to perform cell sorting in a coordinated and automated fashion. The active volume of an actuated valve on this integrated cell sorter can be as small as 1 pL, and the volume of optical interrogation is ∼100 fL. Different algorithms of cell manipulation, including cell trapping, were implemented in these devices. We have also demonstrated sorting and recovery of Escherichia coli cells on the chip.

Item Type:Article
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Arnold, Frances H.0000-0002-4027-364X
Additional Information:© 2002 American Chemical Society. Received 19 January 2002; accepted 11 April 2002; published online 27 April 2002; published in print 1 June 2002. This work was funded in part by the National Science Foundation, the Army Research Office, the DARPA Bioflips program, and NIH HG 01642-04. We also thank Markus Enzelberger for his technical assistance.
Funding AgencyGrant Number
Army Research Office (ARO)UNSPECIFIED
Defense Advanced Research Projects Agency (DARPA)UNSPECIFIED
Issue or Number:11
Record Number:CaltechAUTHORS:20160818-154108271
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Official Citation:Fu, A. Y., Chou, H.-P., Spence, C., Arnold, F. H., & Quake, S. R. (2002). An Integrated Microfabricated Cell Sorter. Analytical Chemistry, 74(11), 2451-2457. doi:10.1021/ac0255330
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69763
Deposited By: Melissa Ray
Deposited On:22 Aug 2016 19:45
Last Modified:11 Nov 2021 04:19

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