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In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry

Garcia-Uribe, Alejandro and Smith, Elizabeth B. and Zou, Jun and Duvic, Madeleine and Prieto, Victor and Wang, Lihong V. (2011) In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry. Journal of Biomedical Optics, 16 (2). Art. No. 020501. ISSN 1083-3668. PMCID PMC3061328. https://resolver.caltech.edu/CaltechAUTHORS:20160819-123246119

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Abstract

In this letter, we report the first use of oblique incidence diffuse reflectance spectrometry to conduct in-vivo measurements of optical properties of three different types of pigmented skin lesions, including melanoma, dysplastic, and common nevi. Both absorption and reduced scattering coefficient spectra were estimated from the spatially resolved diffuse reflectance within the wavelength range of 455–765 nm for 144 pigmented skin lesions including 16 melanomas. The absorption and reduced scattering spectra were found to change with the malignancy of the skin lesions, which were generally higher for the malignant cases than the benign ones. Based on the measurement results, the physiological origin leading to the change of the absorption and scattering properties is also discussed.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/1.3536509DOIArticle
http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1166637PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3061328PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2011 SPIE. Paper 10556LR received Oct. 12, 2010; revised manuscript received Dec. 16, 2010; accepted for publication Dec. 16, 2010; published online Feb. 17, 2011. The authors thank Dr. Mays, Dr. Hymens, and Dr. Mansfield and the staff from the Melanoma and Skin Center at the University of Texas M. D. Anderson Cancer Center for their help during the data collection. This project is sponsored by the National Institute of Health through Grant No. R01 CA106728.
Funders:
Funding AgencyGrant Number
NIHR01 CA106728
Subject Keywords:absorption coefficient; reduced scattering coefficient; diffuse reflectance; and melanoma
Issue or Number:2
PubMed Central ID:PMC3061328
Record Number:CaltechAUTHORS:20160819-123246119
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160819-123246119
Official Citation:Garcia-Uribe A, Smith EB, Zou J, Duvic M, Prieto V, Wang LV; In-vivo characterization of optical properties of pigmented skin lesions including melanoma using oblique incidence diffuse reflectance spectrometry. J. Biomed. Opt. 0001;16(2):020501-020501-3. doi:10.1117/1.3536509
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69793
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:22 Aug 2016 23:54
Last Modified:03 Oct 2019 10:25

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