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MEMS for single-islet electroisletogram

Liu, Y. and Shapero, A. and Zhang, X. and Kang, D. and Park, J. and Xu, L. and Chang, K. and Lin, H. and Ferreri, K. and Tai, Y. C. (2015) MEMS for single-islet electroisletogram. In: 18th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS). IEEE , Piscataway, NJ, pp. 77-80. ISBN 978-1-4799-8955-3. https://resolver.caltech.edu/CaltechAUTHORS:20160826-090759324

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Abstract

This paper reports the first MEMS device designed for in vitro measuring of electroisletogram (EIG) of individual rat islets. Using vacuum to hold an islet in proximity to a microelectrode, strong EIG signals in millivolt range are obtained, while the noise is about 100μV pk-pk. This work proves the feasibility of using MEMS and EIG for high-throughput screening, in contrast to patch-clamp measurements, of islets for transplantation to treat diabetes.


Item Type:Book Section
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1109/TRANSDUCERS.2015.7180865 DOIArticle
http://ieeexplore.ieee.org/document/7180865/?arnumber=7180865PublisherArticle
ORCID:
AuthorORCID
Tai, Y. C.0000-0001-8529-106X
Additional Information:© 2015 IEEE. The authors would greatly thank all the members of California Institute of Technology (Caltech) MEMS lab, especially Mr. Trevor Roper for the maintenance of equipment.
Subject Keywords:Islet, diabetes, multielectrode arrays (MEAs), electroisletogram (EIG)
Record Number:CaltechAUTHORS:20160826-090759324
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160826-090759324
Official Citation:Y. Liu et al., "MEMS for single-islet electroisletogram," 2015 Transducers - 2015 18th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS), Anchorage, AK, 2015, pp. 77-80. doi: 10.1109/TRANSDUCERS.2015.7180865 URL: http://ieeexplore.ieee.org/stamp/stamp.jsp?tp=&arnumber=7180865&isnumber=7180834
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69954
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:26 Aug 2016 16:43
Last Modified:03 Oct 2019 10:26

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