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Tag Team Ubiquitin Ligases

Kleiger, Gary and Deshaies, Raymond (2016) Tag Team Ubiquitin Ligases. Cell, 166 (5). pp. 1080-1081. ISSN 0092-8674.

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Cullin-RING (CRL) and RING1-IBR-RING2 (RBR) are two distinct types of ubiquitin ligases. In this issue, Scott et al. show that CRLs activate the RBR enzyme ARIH1 to initiate ubiquitin chains on CRL substrates, thereby marking an unexpected and important advance in our understanding of both enzymes.

Item Type:Article
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URLURL TypeDescription
Kleiger, Gary0000-0003-3924-1680
Deshaies, Raymond0000-0002-3671-9354
Additional Information:© 2016 Elsevier Inc. R.J.D. is a founder, shareholder, and member of the scientific advisory board of Cleave Biosciences.
Funding AgencyGrant Number
Howard Hughes Medical Institute (HHMI)UNSPECIFIED
Issue or Number:5
Record Number:CaltechAUTHORS:20160829-080930690
Persistent URL:
Official Citation:Gary Kleiger, Raymond Deshaies, Tag Team Ubiquitin Ligases, Cell, Volume 166, Issue 5, 25 August 2016, Pages 1080-1081, ISSN 0092-8674, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69980
Deposited By: Tony Diaz
Deposited On:29 Aug 2016 17:36
Last Modified:09 Mar 2020 13:18

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