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Reflection-mode time-reversed ultrasonically encoded optical focusing into turbid media

Lai, Puxiang and Xu, Xiao and Liu, Honglin and Suzuki, Yuta and Wang, Lihong V. (2011) Reflection-mode time-reversed ultrasonically encoded optical focusing into turbid media. Journal of Biomedical Optics, 16 (8). Art. No. 080505. ISSN 1083-3668. PMCID PMC3166339.

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Time-reversed ultrasonically encoded (TRUE) optical focusing was recently proposed to deliver light dynamically to a tight region inside a scattering medium. In this letter, we report the first development of a reflection-mode TRUE optical focusing system. A high numerical aperture light guide is used to transmit the diffusely reflected light from a turbid medium to a phase-conjugate mirror (PCM), which is sensitive only to the ultrasound-tagged light. From the PCM, a phase conjugated wavefront of the tagged light is generated and conveyed by the same light guide back to the turbid medium, subsequently converging to the ultrasonic focal zone. We present experimental results from this system, which has the ability to focus light in a highly scattering medium with a round-trip optical penetration thickness (extinction coefficient multiplied by round-trip depth) as large as 160.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Liu, Honglin0000-0003-2473-9056
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2011 SPIE. Paper 11206LR received Apr. 25, 2011; revised manuscript received Jun. 16, 2011; accepted for publication Jun. 17, 2011; published online Aug. 11, 2011. The authors thank Professor James Ballard for editing the manuscript. This research is sponsored in part by the NIH through Grants R01 EB000712 and U54 CA136398.
Funding AgencyGrant Number
NIHR01 EB000712
NIHU54 CA136398
Subject Keywords:optical imaging; optical focusing, optical phase conjugation; ultrasonic modulation, time reversal; photorefractive crystal; turbid media; reflection mode
Issue or Number:8
PubMed Central ID:PMC3166339
Record Number:CaltechAUTHORS:20160829-144259641
Persistent URL:
Official Citation:Lai P, Xu X, Liu H, Suzuki Y, Wang LV; Reflection-mode time-reversed ultrasonically encoded optical focusing into turbid media. J. Biomed. Opt. 0001;16(8):080505-080505-3. doi:10.1117/1.3609001
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:69993
Deposited By: Tony Diaz
Deposited On:29 Aug 2016 23:39
Last Modified:09 Mar 2020 13:19

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