CaltechAUTHORS
  A Caltech Library Service

Time-reversed ultrasonically encoded optical focusing into tissue-mimicking media with thickness up to 70 mean free paths

Liu, Honglin and Xu, Xiao and Lai, Puxiang and Wang, Lihong V. (2011) Time-reversed ultrasonically encoded optical focusing into tissue-mimicking media with thickness up to 70 mean free paths. Journal of Biomedical Optics, 16 (8). Art. No. 086009. ISSN 1083-3668. PMCID PMC3162620. https://resolver.caltech.edu/CaltechAUTHORS:20160830-075253136

[img] PDF - Published Version
See Usage Policy.

573Kb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20160830-075253136

Abstract

In turbid media such as biological tissue, multiple scattering hinders direct light focusing at depths beyond one transport mean free path. As a solution to this problem, time-reversed ultrasonically encoded (TRUE) optical focusing is proposed based on ultrasonic encoding of diffused laser light and optical time reversal. In TRUE focusing, a laser beam of long coherence length illuminates a turbid medium, where the incident light undergoes multiple scattering and part of it gets ultrasonically encoded within the ultrasonic focal zone. A conjugated wavefront of the ultrasonically encoded light is then generated by a phase conjugate mirror outside the medium, which traces back the trajectories of the ultrasonically encoded diffused light and converges light to the ultrasonic focal zone. Here, we report the latest experimental improvement in TRUE optical focusing that increases its penetration in tissue-mimicking media from a thickness of 3.75 to 7.00 mm. We also demonstrate that the TRUE focus depends on the focal diameter of the ultrasonic transducer.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1117/1.3609004DOIArticle
http://biomedicaloptics.spiedigitallibrary.org/article.aspx?articleid=1166996PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3162620PubMed CentralArticle
ORCID:
AuthorORCID
Liu, Honglin0000-0003-2473-9056
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2011 SPIE. Paper 11116R received Mar. 9, 2011; revised manuscript received Jun. 15, 2011; accepted for publication Jun. 17, 2011; published online Aug. 1, 2011. The authors appreciate Professor James Ballard’s editing of the manuscript. This research is funded in part by the National Institutes of Health Grant Nos. R01 EB000712 and U54 CA136398.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHU54 CA136398
Subject Keywords:ultrasonic modulation; optical phase conjugation; time reversal; multiple scattering; light manipulation, holographic recording
Issue or Number:8
PubMed Central ID:PMC3162620
Record Number:CaltechAUTHORS:20160830-075253136
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160830-075253136
Official Citation:Liu H, Xu X, Lai P, Wang LV; Time-reversed ultrasonically encoded optical focusing into tissue-mimicking media with thickness up to 70 mean free paths. J. Biomed. Opt. 0001;16(8):086009-086009-6. doi:10.1117/1.3609004
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70013
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:31 Aug 2016 04:41
Last Modified:09 Mar 2020 13:19

Repository Staff Only: item control page