A Caltech Library Service

Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes

Kim, Chulhong and Erpelding, Todd N. and Maslov, Konstantin and Jankovic, Ladislav and Akers, Walter J. and Song, Liang and Achilefu, Samuel and Margenthaler, Julie A. and Pashley, Michael D. and Wang, Lihong V. (2010) Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes. Journal of Biomedical Optics, 15 (4). Art. No. 046010. ISSN 1083-3668. PMCID PMC2937045.

[img] PDF - Published Version
See Usage Policy.


Use this Persistent URL to link to this item:


By modifying a clinical ultrasound array system, we develop a novel handheld photoacoustic probe for image-guided needle biopsy. The integration of optical fiber bundles for pulsed laser light delivery enables photoacoustic image-guided insertion of a needle into rat axillary lymph nodes with accumulated indocyanine green (ICG). Strong photoacoustic contrast of the needle is achieved. After subcutaneous injection of the dye in the left forepaw, sentinel lymph nodes are easily detected, in vivo and in real time, beneath 2-cm 2-cm-thick chicken breast overlaying the axillary region. ICG uptake in axillary lymph nodes is confirmed with fluorescence imaging both in vivo and ex vivo. These results demonstrate the clinical potential of this handheld photoacoustic system for facile identification and needle biopsy of sentinel lymph nodes for cancer staging and metastasis detection in humans.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Maslov, Konstantin0000-0003-3408-8840
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2010 SPIE. Paper 10162R received Mar. 26, 2010; revised manuscript received May 25, 2010; accepted for publication May 28, 2010; published online Aug. 16, 2010. This work was supported in part by grants from the National Institutes of Health (Grants R01 EB000712, R01 EB008085, and U54 CA136398—the Network for Translational Research). L.V.W. has a financial interest in Microphotoacoustics, Inc., and in Endra, Inc., which, however, did not support this work. T.N.E, L.J., and M.D.P are employees of Philips Research.
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHU54 CA136398
Subject Keywords:image-guided needle biopsy; photoacoustic imaging; ultrasound array system; sentinel lymph node biopsy
Issue or Number:4
PubMed Central ID:PMC2937045
Record Number:CaltechAUTHORS:20160830-091304188
Persistent URL:
Official Citation:Kim C, Erpelding TN, Maslov K, et al; Handheld array-based photoacoustic probe for guiding needle biopsy of sentinel lymph nodes. J. Biomed. Opt. 0001;15(4):046010-046010-4
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70020
Deposited By: Tony Diaz
Deposited On:31 Aug 2016 04:25
Last Modified:03 Mar 2020 13:01

Repository Staff Only: item control page