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In Vivo Molecular Photoacoustic Tomography of Melanomas Targeted by Bioconjugated Gold Nanocages

Kim, Chulhong and Cho, Eun Chul and Chen, Jingyi and Song, Kwang Hyun and Au, Leslie and Favazza, Christopher and Zhang, Qiang and Cobley, Claire M. and Gao, Feng and Xia, Younan and Wang, Lihong V. (2010) In Vivo Molecular Photoacoustic Tomography of Melanomas Targeted by Bioconjugated Gold Nanocages. ACS Nano, 4 (8). pp. 4559-4564. ISSN 1936-0851 . PMCID PMC3065066. http://resolver.caltech.edu/CaltechAUTHORS:20160830-095334150

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Abstract

Early diagnosis, accurate staging, and image-guided resection of melanomas remain crucial clinical objectives for improving patient survival and treatment outcomes. Conventional techniques cannot meet this demand because of the low sensitivity, low specificity, poor spatial resolution, shallow penetration, and/or ionizing radiation. Here we overcome such limitations by combining high-resolution photoacoustic tomography (PAT) with extraordinarily optical absorbing gold nanocages (AuNCs). When bioconjugated with [Nle^4,D-Phe^7]-α-melanocyte-stimulating hormone, the AuNCs can serve as a novel contrast agent for in vivo molecular PAT of melanomas with both exquisite sensitivity and high specificity. The bioconjugated AuNCs enhanced contrast ∼300% more than the control, PEGylated AuNCs. The in vivo PAT quantification of the amount of AuNCs accumulated in melanomas was further validated with inductively coupled plasma mass spectrometry (ICP-MS).


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/nn100736cDOIArticle
http://pubs.acs.org/doi/abs/10.1021/nn100736cPublisherArticle
http://pubs.acs.org/doi/suppl/10.1021/nn100736cPublisherSupporting Information
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3065066/PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2010 American Chemical Society. Publication Date (Web): July 13, 2010. This work was supported in part by grants from National Institutes of Health (R01 EB000712, R01 EB008085, and U54 CA136398-the Network for Translational Research-to L.V.W.). L.V.W. has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work. Y.X. thanks the National Institutes of Health for a 2006 Director’s Pioneer Award (DP1 OD000798-04). E.C.C. was also partially supported by a fellowship award from the Korea Research Foundation (KRF-2007-357-D00070) funded by the Korean Government. J.C. was supported by a Pilot Grant from Washington University Molecular Imaging Center.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHU54 CA136398
NIHDP1 OD000798-04
Korea Research FoundationKRF-2007-357-D00070
Washington UniversityUNSPECIFIED
Subject Keywords:photoacoustic tomography; gold nanocages; melanoma; bioconjugation; molecular imaging
PubMed Central ID:PMC3065066
Record Number:CaltechAUTHORS:20160830-095334150
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160830-095334150
Official Citation:In Vivo Molecular Photoacoustic Tomography of Melanomas Targeted by Bioconjugated Gold Nanocages Chulhong Kim, Eun Chul Cho, Jingyi Chen, Kwang Hyun Song, Leslie Au, Christopher Favazza, Qiang Zhang, Claire M. Cobley, Feng Gao, Younan Xia, and Lihong V. Wang ACS Nano 2010 4 (8), 4559-4564 DOI: 10.1021/nn100736c
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70023
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:31 Aug 2016 04:21
Last Modified:31 Aug 2016 04:21

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