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In Vivo Photoacoustic Tomography of Chemicals: High-Resolution Functional and Molecular Optical Imaging at New Depths

Kim, Chulhong and Favazza, Christopher and Wang, Lihong V. (2010) In Vivo Photoacoustic Tomography of Chemicals: High-Resolution Functional and Molecular Optical Imaging at New Depths. Chemical Reviews, 110 (5). pp. 2756-2782. ISSN 0009-2665. PMCID PMC2872199. https://resolver.caltech.edu/CaltechAUTHORS:20160830-103451115

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Abstract

High-resolution volumetric optical imaging modalities, such as confocal microscopy, two-photon microscopy, and optical coherence tomography, have become increasingly important in the biomedical imaging field. However, due to strong light scattering, the penetration depths of these imaging modalities are limited to the optical transport mean free path in biological tissues, for example, ∼1 mm in the skin. Photoacoustic tomography (PAT), an emerging hybrid imaging modality that can provide strong endogenous and exogenous optical absorption contrasts with high ultrasonic spatial resolution using the photoacoustic (PA) effect, has overcome the fundamental depth limitation. The image resolution is scalable with the ultrasonic frequency. The imaging depth is limited to the reach of photons and up to a few centimeters deep in biological tissues. This Review will focus on the following aspects of PAT described in works published from 2003 to 2009: (1) multiscale PAT systems, (2) morphological and functional PAT using intrinsic contrasts (hemoglobin or melanin), and (3) functional and molecular PAT using exogenous contrast agents (organic dyes, nanoparticles, reporter genes, or fluorescence proteins).


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/cr900266sDOIArticle
http://pubs.acs.org/doi/abs/10.1021/cr900266sPublisherArticle
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872199PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2010 American Chemical Society. Published on Web 03/08/2010. We appreciate Professor James Ballard’s close reading of the manuscript and Song Hu for cover art. This work was sponsored in part by National Institutes of Health grants R01 EB000712, R01 EB008085, R01 CA113453901, U54 CA136398, and 5P60 DK02057933. L.V.W. has a financial interest in Microphotoacoustics, Inc., and Endra, Inc., which, however, did not support this work.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA113453901
NIHU54 CA136398
NIH5P60 DK02057933
Issue or Number:5
PubMed Central ID:PMC2872199
Record Number:CaltechAUTHORS:20160830-103451115
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160830-103451115
Official Citation:In Vivo Photoacoustic Tomography of Chemicals: High-Resolution Functional and Molecular Optical Imaging at New Depths Chulhong Kim, Christopher Favazza, and Lihong V. Wang Chemical Reviews 2010 110 (5), 2756-2782 DOI: 10.1021/cr900266s
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70034
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:31 Aug 2016 04:12
Last Modified:03 Oct 2019 10:27

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