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Label-free photoacoustic ophthalmic angiography

Hu, Song and Rao, Bin and Maslov, Konstantin and Wang, Lihong V. (2010) Label-free photoacoustic ophthalmic angiography. Optics Letters, 35 (1). pp. 1-3. ISSN 0146-9592. PMCID PMC2912610.

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We present label-free functional photoacoustic imaging of the ocular microvasculature in living animals. The anterior segment of an adult mouse was imaged with a laser exposure level well within the American National Standards Institute safety standards. Individual red blood cells traveling along the iris capillaries were clearly resolved, and the hemoglobin oxygen saturation in the iris microvasculature was imaged spectrally. We believe that photoacoustic imaging has the potential to advance the diagnosis and treatment of ocular diseases in humans.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Rao, Bin0000-0001-6494-3110
Maslov, Konstantin0000-0003-3408-8840
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2010 Optical Society of America. Received September 10, 2009; revised November 15, 2009; accepted November 16, 2009; posted November 19, 2009 (Doc. ID 116816); published December 17, 2009. The authors appreciate Professor James Ballard’s close reading of the manuscript. This work was sponsored by the National Institutes of Health (NIH) grants R01 EB000712, R01 NS46214, R01 EB008085, and U54 CA136398. L. V. Wang has a financial interest in Microphotoacoustics, Inc. and Endra, Inc., which, however, did not support this work.
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 NS46214
NIHR01 EB008085
NIHU54 CA136398
Issue or Number:1
Classification Code:OCIS codes: 170.3880, 170.5120, 330.7327, 140.3360
PubMed Central ID:PMC2912610
Record Number:CaltechAUTHORS:20160907-152405107
Persistent URL:
Official Citation:S. Hu, B. Rao, K. Maslov, and L. Wang, "Label-free photoacoustic ophthalmic angiography," Opt. Lett. 35, 1-3 (2010)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70199
Deposited By: Tony Diaz
Deposited On:08 Sep 2016 16:39
Last Modified:09 Mar 2020 13:19

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