A Caltech Library Service

Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging

Kim, Chulhong and Qin, Ruogu and Xu, Jeff S. and Wang, Lihong V. and Xu, Ronald (2010) Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging. Journal of Biomedical Optics, 15 (1). Art. No. 010510. ISSN 1083-3668. PMCID PMC2839794.

[img] PDF - Published Version
See Usage Policy.


Use this Persistent URL to link to this item:


We develop a novel dual-modal contrast agent—encapsulated-ink poly(lactic-co-glycolic acid) (PLGA) microbubbles and nanobubbles—for photoacoustic and ultrasound imaging. Soft gelatin phantoms with embedded tumor simulators of encapsulated-ink PLGA microbubbles and nanobubbles in various concentrations are clearly shown in both photoacoustic and ultrasound images. In addition, using photoacoustic imaging, we successfully image the samples positioned below 1.8-cm-thick chicken breast tissues. Potentially, simultaneous photoacoustic and ultrasound imaging enhanced by encapsulated-dye PLGA microbubbles or nanobubbles can be a valuable tool for intraoperative assessment of tumor boundaries and therapeutic margins.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2010 SPIE. Paper 09505LR received Nov. 13, 2009; revised manuscript received Jan. 1, 2010; accepted for publication Jan. 6, 2010; published online Feb. 18, 2010. This work was supported in part by grants from the National Institutes of Health (R01 EB000712, R01 EB008085, R01 CA113453901, U54 CA136398—the Network for Translational Research, and 5P60 DK02057933 to Wang), and the Department of Defense Breast Cancer Research Program (W81XWH-07 to Xu). Wang has a financial interest in Microphotoacoustics, Incorporated, and in Endra, Incorporated, which, however, did not support this work.
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 EB008085
NIHR01 CA113453901
NIHU54 CA136398
NIH5P60 DK02057933
Department of DefenseW81XWH-07
Subject Keywords:microbubbles; nanobubbles; photoacoustic imaging; ultrasound imaging; tumor margin intraoperative assessment
Issue or Number:1
PubMed Central ID:PMC2839794
Record Number:CaltechAUTHORS:20160907-155320765
Persistent URL:
Official Citation:Kim C, Qin R, Xu JS, Wang LV, Xu R; Multifunctional microbubbles and nanobubbles for photoacoustic and ultrasound imaging. J. Biomed. Opt. 0001;15(1):010510-010510-3
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70200
Deposited By: Tony Diaz
Deposited On:08 Sep 2016 16:35
Last Modified:03 Oct 2019 10:28

Repository Staff Only: item control page