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Spectral hole burning for ultrasound-modulated optical tomography of thick tissue

Xu, Xiao and Kothapalli, Sri-Rajasekhar and Liu, Honglin and Wang, Lihong V. (2010) Spectral hole burning for ultrasound-modulated optical tomography of thick tissue. Journal of Biomedical Optics, 15 (6). Art. No. 066018. ISSN 1083-3668. PMCID PMC3017574.

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We apply spectral hole burning (SHB)-aided detection in ultrasound-modulated optical tomography (UOT) to image optical heterogeneities in thick tissue-mimicking phantom samples and chicken breast tissue. The efficiency of SHB is improved by using a Tm^(3+):YAG crystal of higher doping concentration (2.0-atomic%) and a double-pass pumping configuration, in which the pump beam is transmitted through the crystal twice to burn a deeper spectral hole with the available optical intensity. With the improved SHB-UOT system, we image absorbing, scattering, and phase objects that are embedded in the middle plane of a 30-mm-thick phantom sample. The imaging resolution was 0.5 mm in the lateral direction, as defined by the focal width of the ultrasonic transducer, and 1.5 mm in the axial direction, as determined by the ultrasonic burst length. We also image two absorbing objects embedded in a 32-mm-thick chicken breast sample. The results suggest that the improved SHB-UOT system is one step closer to the practical optical imaging application in biological and clinical studies.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Liu, Honglin0000-0003-2473-9056
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2010 SPIE. Paper 10488LR received Sep. 1, 2010; revised manuscript received Sep. 28, 2010; accepted for publication Sep. 29, 2010; published online Dec. 13, 2010; corrected Dec. 16, 2010. We are thankful to Chulhong Kim for his assistance with an early system setup. This research is funded in part by the National Institutes of Health grants R01 EB000712 and U54 CA136398..
Funding AgencyGrant Number
NIHR01 EB000712
NIHU54 CA136398
Subject Keywords:ultrasound-modulated optical tomography; optical imaging; spectral hole burning; scattering medium; diffuse medium
Issue or Number:6
PubMed Central ID:PMC3017574
Record Number:CaltechAUTHORS:20160920-084957348
Persistent URL:
Official Citation:Xu X, Kothapalli S, Liu H, Wang LV; Spectral hole burning for ultrasound-modulated optical tomography of thick tissue. J. Biomed. Opt. 0001;15(6):066018-066018-5
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70451
Deposited By: Tony Diaz
Deposited On:29 Sep 2016 21:06
Last Modified:09 Mar 2020 13:19

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