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A real-time photoacoustic tomography system for small animals

Gamelin, John and Maurudis, Anastasios and Aguirre, Andres and Huang, Fei and Guo, Puyun and Wang, Lihong V. and Zhu, Quing (2009) A real-time photoacoustic tomography system for small animals. Optics Express, 17 (13). pp. 10489-10498. ISSN 1094-4087. PMCID PMC2757438. https://resolver.caltech.edu/CaltechAUTHORS:20160920-153732241

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Abstract

A real-time 512-element photoacoustic tomography system for small animal imaging using a ring ultrasound array has been developed. The system, based upon a 5 MHz transducer array formed along a 50 mm circular aperture, achieves sub-200 micron lateral resolution over a 2 cm disk-shaped region. Corresponding elevation resolutions of 0.6 to 2.5 mm over the central volume enable depth-resolved 3D tomographic imaging with linear translation. Using 8:1 electronic multiplexing, imaging at up to 8 frame/sec is demonstrated for both dynamic phantoms and in vivo mouse and brain samples. The real-time, full 2D tomographic capability of the system paves the way for functional photoacoustic tomographic imaging studies in small animals with sub-second time frame.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1364/OE.17.010489DOIArticle
https://www.osapublishing.org/oe/abstract.cfm?uri=oe-17-13-10489PublisherArticle
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2757438PubMed CentralArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2009 Optical Society of America. Received 3 Apr 2009; revised 17 May 2009; accepted 18 May 2009; published 8 Jun 2009. We acknowledge the funding support from NIH (R01 NS46214) and The Donaghue Medical Research Foundation.
Funders:
Funding AgencyGrant Number
NIHR01 NS46214
Donaghue Medical Research FoundationUNSPECIFIED
Issue or Number:13
Classification Code:OCIS codes: (110.0110) Imaging Systems; (170.0170) Medical Optics and Biotechnology; (110.5120) Photoacoustic Imaging; (170.3880) Medical and Biological Imaging; (170.3890); Medical Optics Instrumentation; (170.6960) Tomography
PubMed Central ID:PMC2757438
Record Number:CaltechAUTHORS:20160920-153732241
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160920-153732241
Official Citation:John Gamelin, Anastasios Maurudis, Andres Aguirre, Fei Huang, Puyun Guo, Lihong V. Wang, and Quing Zhu, "A real-time photoacoustic tomography system for small animals," Opt. Express 17, 10489-10498 (2009)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70475
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:28 Sep 2016 23:48
Last Modified:03 Oct 2019 10:31

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