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Near-Infrared Gold Nanocages as a New Class of Tracers for Photoacoustic Sentinel Lymph Node Mapping on a Rat Model

Song, Kwang Hyun and Kim, Chulhong and Cobley, Claire M. and Xia, Younan and Wang, Lihong V. (2009) Near-Infrared Gold Nanocages as a New Class of Tracers for Photoacoustic Sentinel Lymph Node Mapping on a Rat Model. Nano Letters, 9 (1). pp. 183-188. ISSN 1530-6984. http://resolver.caltech.edu/CaltechAUTHORS:20160921-095657414

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Abstract

This work demonstrated the use of Au nanocages as a new class of lymph node tracers for noninvasive photoacoustic (PA) imaging of a sentinel lymph node (SLN). Current SLN mapping methods based on blue dye and/or nanometer-sized radioactive colloid injection are intraoperative due to the need for visual detection of the blue dye and low spatial resolution of Geiger counters in detecting radioactive colloids. Compared to the current methods, PA mapping based on Au nanocages shows a number of attractive features: noninvasiveness, strong optical absorption in the near-infrared region (for deep penetration), and the accumulation of Au nanocages with a higher concentration than the initial solution for the injection. In an animal model, these features allowed us to identify SLNs containing Au nanocages as deep as 33 mm below the skin surface with good contrast. Most importantly, compared to methylene blue Au nanocages can be easily bioconjugated with antibodies for targeting specific receptors, potentially eliminating the need for invasive axillary staging procedures in addition to providing noninvasive SLN mapping.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/nl802746wDOIArticle
http://pubs.acs.org/doi/abs/10.1021/nl802746wPublisherArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2008 American Chemical Society. Received September 10, 2008; Revised Manuscript Received November 19, 2008. Publication Date (Web): December 10, 2008. This research was sponsored in part by Grants from National Institutes of Health (R01 EB000712 and R01 NS46214 to L.V.W.). L.V.W. has a financial interest in Endra, Inc., which did not support this work. Y.X. thanks the National Institutes of Health for a 2006 Director’s Pioneer Award (5DP1OD000798-04).
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 NS46214
NIH5DP1OD000798-04
Record Number:CaltechAUTHORS:20160921-095657414
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160921-095657414
Official Citation:Near-Infrared Gold Nanocages as a New Class of Tracers for Photoacoustic Sentinel Lymph Node Mapping on a Rat Model Kwang Hyun Song, Chulhong Kim, Claire M. Cobley, Younan Xia, and Lihong V. Wang Nano Letters 2009 9 (1), 183-188 DOI: 10.1021/nl802746w
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70494
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:29 Sep 2016 20:45
Last Modified:29 Sep 2016 20:45

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