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Optical fluence distribution study in tissue in dark-field confocal photoacoustic microscopy using a modified Monte Carlo convolution method

Xie, Zhixing and Wang, Lihong V. and Zhang, Hao F. (2009) Optical fluence distribution study in tissue in dark-field confocal photoacoustic microscopy using a modified Monte Carlo convolution method. Applied Optics, 48 (17). pp. 3204-3211. ISSN 0003-6935. http://resolver.caltech.edu/CaltechAUTHORS:20160921-103418975

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Abstract

We have modified the existing convolution method of the Monte Carlo simulation for finite photon beams with both translational and rotational invariance. The modified convolution method was applied to simulate the optical fluence distribution in tissue in dark-field confocal photoacoustic microscopy. We studied the influence of the size of the dark field and the illumination incident angle on the depth position of the effective optical focus (the region with the highest fluence) and the fluence ratio (the ratio of the optical fluence at the effective optical focus inside the tissue to the optical fluence on the tissue surface along the ultrasonic axis). Within the reach of diffuse photons, the depth position of the effective optical focus increases with the size of the dark field and is much less sensitive to the incident angle. The findings show that, while the fluence at the effective optical focus decreases, the fluence ratio increases with the size of the dark field. The incident angle has a weaker influence on the fluence ratio than the size of the dark field does. An incident angle between 30 and 50 degrees gives the highest fluence at the effective optical focus.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1364/AO.48.003204DOIArticle
https://www.osapublishing.org/ao/abstract.cfm?uri=ao-48-17-3204PublisherArticle
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2009 Optical Society of America. Received 22 August 2008; revised 7 May 2009; accepted 13 May 2009; posted 13 May 2009 (Doc. ID 100461); published 5 June 2009. This work was supported in part by The University of Wisconsin-Milwaukee startup fund and by a grant from The Lynde and Harry Bradley Foundation. We also thank Dr. Konstantin Maslov and Dr. Gang Yao for valuable discussions.
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Funding AgencyGrant Number
University of Wisconsin-Milwaukee UNSPECIFIED
Lynde and Harry Bradley FoundationUNSPECIFIED
Record Number:CaltechAUTHORS:20160921-103418975
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20160921-103418975
Official Citation:Zhixing Xie, Lihong V. Wang, and Hao F. Zhang, "Optical fluence distribution study in tissue in dark-field confocal photoacoustic microscopy using a modified Monte Carlo convolution method," Appl. Opt. 48, 3204-3211 (2009)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70499
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:29 Sep 2016 20:39
Last Modified:29 Sep 2016 20:39

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