A Caltech Library Service

In vivo burn imaging using Mueller optical coherence tomography

Todorovic, Miloš and Jiao, Shuliang and Ai, Jun and Pereda-Cubián, David and Stoica, George and Wang, Lihong V. (2008) In vivo burn imaging using Mueller optical coherence tomography. Optics Express, 16 (14). pp. 10279-10284. ISSN 1094-4087. PMCID PMC6986309. doi:10.1364/OE.16.010279.

[img] PDF - Published Version
See Usage Policy.

[img] PDF - Accepted Version
See Usage Policy.


Use this Persistent URL to link to this item:


We report on the use of a high-speed, fiber-based Mueller-matrix optical coherence tomography system with continuous source-polarization modulation for in vivo burn depth evaluation and healing monitoring. A homemade hand-held probe with integrated optical scanning and beam delivering optics was coupled in the sample arm. In vivo burn imaging was demonstrated on porcine skin at different stages of the wound healing process, where porcine skin was used because of its similarity to the human skin. Thermally damaged region was clearly localized in the depth-resolved phase retardation image extracted from the measured Jones matrix. The burn areas in the OCT images agreed well with the histology. By using a decomposition algorithm developed by our group, we also mapped the local birefringence of the skin. The experimental results demonstrate the system’s potential for in vivo burn-depth determination.

Item Type:Article
Related URLs:
URLURL TypeDescription CentralArticle
Stoica, George0000-0001-8071-4828
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2008 Optical Society of America. Received 7 Mar 2008; revised 16 May 2008; accepted 16 May 2008; published 26 Jun 2008. This project was sponsored in part by the Department of the Army (Cooperative Agreement Number: DAMD17-97-2-7016) and the National Institutes of Health (R01 CA092415). The content of the information presented in this paper does not necessarily reflect the position or the policy of the government or NMTB. No official endorsement should be inferred.
Funding AgencyGrant Number
Department of the ArmyDAMD17-97-2-7016
NIHR01 CA092415
Issue or Number:14
Classification Code:OCIS codes: (170.1650) Coherence imaging; (170.3880) Medical and biological imaging; (170.4500) Optical coherence tomography; (260.1440) Birefringence; (260.5430) Polarization; (290.7050) Turbid media
PubMed Central ID:PMC6986309
Record Number:CaltechAUTHORS:20160923-135417190
Persistent URL:
Official Citation:Miloš Todorović, Shuliang Jiao, Jun Ai, David Pereda-Cubián, George Stoica, and Lihong V. Wang, "In vivo burn imaging using Mueller optical coherence tomography," Opt. Express 16, 10279-10284 (2008)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70563
Deposited By: Tony Diaz
Deposited On:28 Sep 2016 23:39
Last Modified:11 Nov 2021 04:31

Repository Staff Only: item control page