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Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy

Zhang, Hao F. and Maslov, Konstantin and Sivaramakrishnan, Mathangi and Stoica, Gheorghe and Wang, Lihong V. (2007) Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy. Applied Physics Letters, 90 (5). Art. No. 053901. ISSN 0003-6951. doi:10.1063/1.2435697. https://resolver.caltech.edu/CaltechAUTHORS:20160927-122347693

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Abstract

Photoacoustic microscopy was used to noninvasively image variations in hemoglobin oxygen saturation (SO_2) in the subcutaneous microvasculature of rats in vivo. In phantom tests, the calculated concentration fractions of red ink in double-ink mixtures matched the actual values with a 1% error. In ex vivo studies, the calculated SO_2 in bovine blood agreed with the standard spectrophotometric measurements within a 4% systematic difference. In in vivo studies, arteries and veins were separated based on the measured SO_2 values and variations in SO_2 between different physiological states (hyperoxia, normoxia, and hypoxia) were imaged in single blood vessels.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1063/1.2435697DOIArticle
http://scitation.aip.org/content/aip/journal/apl/90/5/10.1063/1.2435697PublisherArticle
ORCID:
AuthorORCID
Maslov, Konstantin0000-0003-3408-8840
Stoica, Gheorghe0000-0001-8071-4828
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2007 American Institute of Physics. Received 4 April 2006; accepted 21 December 2006; published online 29 January 2007. The authors thank O. Craciun, G. Ku, and G. Lungu for experimental assistance. This work was sponsored by National Institutes of Health Grant Nos. R01 EB000712 and R01 NS46214.
Funders:
Funding AgencyGrant Number
NIHR01 EB000712
NIHR01 NS46214
Issue or Number:5
DOI:10.1063/1.2435697
Record Number:CaltechAUTHORS:20160927-122347693
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160927-122347693
Official Citation:Imaging of hemoglobin oxygen saturation variations in single vessels in vivo using photoacoustic microscopy Zhang, Hao F. and Maslov, Konstantin and Sivaramakrishnan, Mathangi and Stoica, Gheorghe and Wang, Lihong V., Applied Physics Letters, 90, 053901 (2007), DOI:http://dx.doi.org/10.1063/1.2435697
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70613
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:28 Sep 2016 22:56
Last Modified:11 Nov 2021 04:32

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