CaltechAUTHORS
  A Caltech Library Service

Multiplicity of morphologies in poly (L-lactide) bioresorbable vascular scaffolds

Ailianou, Artemis and Ramachandran, Karthik and Kossuth, Mary Beth and Oberhauser, James Paul and Kornfield, Julia A. (2016) Multiplicity of morphologies in poly (L-lactide) bioresorbable vascular scaffolds. Proceedings of the National Academy of Sciences of the United States of America, 113 (42). pp. 11670-11675. ISSN 0027-8424. PMCID PMC5081625. https://resolver.caltech.edu/CaltechAUTHORS:20160928-105122973

[img] PDF - Published Version
See Usage Policy.

2040Kb
[img] PDF - Supplemental Material
See Usage Policy.

2549Kb

Use this Persistent URL to link to this item: https://resolver.caltech.edu/CaltechAUTHORS:20160928-105122973

Abstract

Poly(L-lactide) (PLLA) is the structural material of the first clinically approved bioresorbable vascular scaffold (BVS), a promising alternative to permanent metal stents for treatment of coronary heart disease. BVSs are transient implants that support the occluded artery for 6 mo and are completely resorbed in 2 y. Clinical trials of BVSs report restoration of arterial vasomotion and elimination of serious complications such as late stent thrombosis. It is remarkable that a scaffold made from PLLA, known as a brittle polymer, does not fracture when crimped onto a balloon catheter or during deployment in the artery. We used X-ray microdiffraction to discover how PLLA acquired ductile character and found that the crimping process creates localized regions of extreme anisotropy; PLLA chains in the scaffold change orientation from the hoop direction to the radial direction on micrometer-scale distances. This multiplicity of morphologies in the crimped scaffold works in tandem to enable a low-stress response during deployment, which avoids fracture of the PLLA hoops and leaves them with the strength needed to support the artery. Thus, the transformations of the semicrystalline PLLA microstructure during crimping explain the unexpected strength and ductility of the current BVS and point the way to thinner resorbable scaffolds in the future.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1073/pnas.1602311113DOIArticle
http://www.pnas.org/content/113/42/11670PublisherArticle
http://www.pnas.org/lookup/suppl/doi:10.1073/pnas.1602311113/-/DCSupplementalPublisherSupporting Information
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5081625/PubMed CentralArticle
ORCID:
AuthorORCID
Ramachandran, Karthik0000-0003-1820-7555
Kornfield, Julia A.0000-0001-6746-8634
Additional Information:© 2016 National Academy of Sciences. Edited by John A. Rogers, University of Illinois, Urbana, IL, and approved August 12, 2016 (received for review April 22, 2016) This research used resources of the Advanced Photon Source (APS), a US Department of Energy (DOE) Office of Science User Facility operated for the DOE Office of Science by Argonne National Laboratory under Contract DE-AC02-06CH11357. We thank Dr. Zhonghou Cai at APS for his assistance in collecting x-ray microdiffraction data, and Mr. Troy P. Carter (Abbott Vascular) for sectioning the scaffolds. We appreciate the assistance of Dr. Nobumichi Tamura at the Advanced Light Source, Lawrence Berkeley National Laboratories, for proof-of-concept x-ray microdiffraction measurements. The Advanced Light Source is supported by the Director, Office of Science, Office of Basic Energy Sciences, of the US Department of Energy under Contract DE-AC02-05CH1123. Funding for this research was provided by Abbot Vascular. A.A and K.R contributed equally to this work. Author contributions: A.A., K.R., and J.A.K. designed research; A.A. and K.R. performed research; M.B.K., J.P.O., and J.A.K. contributed new reagents/analytic tools; A.A., K.R., and J.A.K. analyzed data; and A.A., K.R., and J.A.K. wrote the paper. Conflict of interest statement: M.B.K. and J.P.O. are employees of Abbott Vascular. Funding for this research was provided by Abbott Vascular. This article is a PNAS Direct Submission. This article contains supporting information online at www.pnas.org/lookup/suppl/doi:10.1073/pnas.1602311113/-/DCSupplemental.
Funders:
Funding AgencyGrant Number
Department of Energy (DOE)DE-AC02-06CH11357
Department of Energy (DOE)DE-AC02-05CH1123
Abbot VascularUNSPECIFIED
Subject Keywords:structural transformation; ductility; poly (L-lactide); coronary heart disease; microdiffraction
Issue or Number:42
PubMed Central ID:PMC5081625
Record Number:CaltechAUTHORS:20160928-105122973
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20160928-105122973
Official Citation:Artemis Ailianou, Karthik Ramachandran, Mary Beth Kossuth, James Paul Oberhauser, and Julia A. Kornfield Multiplicity of morphologies in poly (L-lactide) bioresorbable vascular scaffolds PNAS 2016 113 (42) 11670-11675; published ahead of print September 26, 2016, doi:10.1073/pnas.1602311113
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70635
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:28 Sep 2016 18:02
Last Modified:09 Mar 2020 13:19

Repository Staff Only: item control page