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High Molecular Weight Nonribosomal-Type Nuclear RNA and Cytoplasmic Messenger RNA in Hela Cells

Houssais, Jean-François and Attardi, Giuseppe (1966) High Molecular Weight Nonribosomal-Type Nuclear RNA and Cytoplasmic Messenger RNA in Hela Cells. Proceedings of the National Academy of Sciences of the United States of America, 56 (2). pp. 616-623. ISSN 0027-8424.

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As reported elsewhere,[1] the study of RNA synthesis in vitro in immature duck erythrocytes has revealed the occurrence in the nucleus of fast turning-over RNA of high molecular weight (from 2 X 10^6 to 10^7, or possibly more) and with base composition different from that of ribosomal RNA, and characterized by a high U and relatively low GC content. No relationship of precursor-to-product type -- or, at any rate, not a simple one-appears to exist between this RNA and the messenger RNA fraction associated with cytoplasmic polysomes. In this paper, evidence is presented indicating that this class of nuclear RNA molecules is not exclusive of immature erythrocytes, or in general of nondividing cells undergoing differentiation, but occurs also in exponentially growing cells.

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Additional Information:Copyright © 1966 by National Academy of Sciences Commnunicated by Norman Davidson, May 23, 1966. This work was supported by a research grant from the U.S. Public Health Service (GM-11726). One of the authors (J.-F. Houssais) is a Fellow of Comite de Biologie Moleculaire, Delegation General a la Recherche Scientifique et Technique, Paris, France. The authors would like to thank Mrs. LaVerne Wenzel and Mrs. Benneta Keeley for their excellent assistance.
Issue or Number:2
Record Number:CaltechAUTHORS:HOUpnas66
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Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:707
Deposited By: Archive Administrator
Deposited On:15 Sep 2005
Last Modified:02 Oct 2019 22:36

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