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A Membrane-Associated RNA of Cytoplasmic Origin in Hela Cells

Attardi, Barbara and Attardi, Giuseppe (1967) A Membrane-Associated RNA of Cytoplasmic Origin in Hela Cells. Proceedings of the National Academy of Sciences of the United States of America, 58 (3). pp. 1051-1058. ISSN 0027-8424. http://resolver.caltech.edu/CaltechAUTHORS:ATTpnas67

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Abstract

The genetic evidence of the existence in yeast [1] and molds [2] of cytoplasmic determinants controlling the structure and function of mitochondria and the demonstration that mitochondria from all organisms contain DNA [3-7] have indicated that transcription and translation processes dependent on cytoplasmic genes occur in eukaryotic cells. More recent observations in Neurospora have suggested that a cytoplasmic, presumably mitochondrial, genetic determinant controls the structural proteins of different membrane systems (mitochondria, microsomes, nuclear membrane) [8, 9]; these structural proteins, from their amino acid composition, fingerprinting pattern, and immunological behavior, appear to be identical or to have a common component. [8, 9] These findings suggest that cytoplasmic genes may have a wider role in the cell than hitherto suspected and may direct a considerable fraction of mRNA and protein synthesis.


Item Type:Article
Additional Information:Copyright © 1967 by National Academy of Sciences Communicated by Renato Dulbecco, June 23, 1967. This work was supported by a research grant from the U.S. Public Health Service (GM-11726). One of us (B. A.) was supported by a National Defense and Education Act Fellowship. The excellent assistance of Mrs. LaVerne Wenzel and Mrs. Benneta Keeley is gratefully acknowledged.
Issue or Number:3
Record Number:CaltechAUTHORS:ATTpnas67
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:ATTpnas67
Alternative URL:http://www.pnas.org/cgi/reprint/58/3/1051
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:708
Collection:CaltechAUTHORS
Deposited By: Archive Administrator
Deposited On:15 Sep 2005
Last Modified:14 Nov 2014 19:18

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