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Growth of nano-scale hydroxyapatite using chemically treated titanium oxide nanotubes

Oh, Seung-Han and Finoñes, Rita R. and Daraio, Chiara and Chen, Li-Han and Jin, S. (2005) Growth of nano-scale hydroxyapatite using chemically treated titanium oxide nanotubes. Biomaterials, 26 (24). pp. 4938-4943. ISSN 0142-9612. doi:10.1016/j.biomaterials.2005.01.048.

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A vertically aligned nanotube array of titanium oxide was fabricated on the surface of titanium substrate by anodization. The nanotubes were then treated with NaOH solution to make them bioactive, and to induce growth of hydroxyapatite (bone-like calcium phosphate) in a simulated body fluid. It is shown that the presence of TiO_2 nanotubes induces the growth of a “nano-inspired nanostructure”, i.e., extremely fine-scale (∼8 nm feature) nanofibers of bioactive sodium titanate structure on the top edge of the ∼15 nm thick nanotube wall. During the subsequent in-vitro immersion in a simulated body fluid, the nano-scale sodium titanate, in turn, induced the nucleation and growth nano-dimensioned hydroxyapatite (HAp) phase. The kinetics of HAp formation is significantly accelerated by the presence of the nanostructures. Such TiO_2 nanotube arrays and associated nanostructures can be useful as a well-adhered bioactive surface layer on Ti implant metals for orthopaedic and dental implants, as well as for photocatalysts and other sensor applications.

Item Type:Article
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Daraio, Chiara0000-0001-5296-4440
Additional Information:© 2005 Elsevier Ltd. Received 15 October 2004; accepted 17 January 2005. The authors wish to thank A.I. Gapin and T. Pisanic at UC San Diego for helpful discussions and assistance in experiments. This work was partly supported by K. Iwama Endowed Chair fund.
Funding AgencyGrant Number
K. Iwama Endowed Chair FundUNSPECIFIED
Subject Keywords:Nanostructure; Hydroxyapatite; TiO2; Nanotubes; Implant; Bone
Issue or Number:24
Record Number:CaltechAUTHORS:20161004-101004335
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Official Citation:Seung-Han Oh, Rita R. Finõnes, Chiara Daraio, Li-Han Chen, Sungho Jin, Growth of nano-scale hydroxyapatite using chemically treated titanium oxide nanotubes, Biomaterials, Volume 26, Issue 24, August 2005, Pages 4938-4943, ISSN 0142-9612, (
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70808
Deposited By: Tony Diaz
Deposited On:04 Oct 2016 18:09
Last Modified:11 Nov 2021 04:34

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