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Determination of the connectivity of newborn neurons in mammalian olfactory circuits

Ravi, Namasivayam and Sánchez-Guardado, Luis and Lois, Carlos and Kelsch, Wolfgang (2017) Determination of the connectivity of newborn neurons in mammalian olfactory circuits. Cellular and Molecular Life Sciences, 74 (5). pp. 849-867. ISSN 1420-682X. https://resolver.caltech.edu/CaltechAUTHORS:20161005-072343756

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Abstract

The mammalian olfactory bulb is a forebrain structure just one synapse downstream from the olfactory sensory neurons and performs the complex computations of sensory inputs. The formation of this sensory circuit is shaped through activity-dependent and cell-intrinsic mechanisms. Recent studies have revealed that cell-type specific connectivity and the organization of synapses in dendritic compartments are determined through cell-intrinsic programs already preset in progenitor cells. These progenitor programs give rise to subpopulations within a neuron type that have distinct synaptic organizations. The intrinsically determined formation of distinct synaptic organizations requires factors from contacting cells that match the cell-intrinsic programs. While certain genes control wiring within the newly generated neurons, other regulatory genes provide intercellular signals and are only expressed in neurons that will form contacts with the newly generated cells. Here, the olfactory system has provided a useful model circuit to reveal the factors regulating assembly of the highly structured connectivity in mammals.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1007/s00018-016-2367-yDOIArticle
http://link.springer.com/article/10.1007%2Fs00018-016-2367-yPublisherArticle
http://rdcu.be/tsQrPublisherFree ReadCube access
ORCID:
AuthorORCID
Sánchez-Guardado, Luis0000-0001-5598-8608
Lois, Carlos0000-0002-7305-2317
Kelsch, Wolfgang0000-0002-3470-8125
Additional Information:© 2016 Springer International Publishing. Received: 22 May 2016; Revised: 24 August 2016; Accepted: 13 September 2016. Published Online: 30 September 2016. The work was funded by DFG KE1661/1-1 to W.K. The authors declare no competing financial interests.
Funders:
Funding AgencyGrant Number
Deutsche Forschungsgemeinschaft (DFG)KE1661/1-1
Subject Keywords:Development; Synaptogenesis; Cell fate; Transcription factor; Mouse
Issue or Number:5
Record Number:CaltechAUTHORS:20161005-072343756
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161005-072343756
Official Citation:Ravi, N., Sanchez-Guardado, L., Lois, C. et al. Cell. Mol. Life Sci. (2017) 74: 849. doi:10.1007/s00018-016-2367-y
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70849
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 Oct 2016 15:02
Last Modified:08 Oct 2019 21:30

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