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Effects of wavelength-dependent fluence attenuation on the noninvasive photoacoustic imaging of hemoglobin oxygen saturation in subcutaneous vasculature in vivo

Maslov, Konstantin and Zhang, Hao F. and Wang, Lihong V. (2007) Effects of wavelength-dependent fluence attenuation on the noninvasive photoacoustic imaging of hemoglobin oxygen saturation in subcutaneous vasculature in vivo. Inverse Problems, 23 (6). S113-S122. ISSN 0266-5611. doi:10.1088/0266-5611/23/6/S09. https://resolver.caltech.edu/CaltechAUTHORS:20161005-074721592

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Abstract

Quantitative measurements of the oxygen saturation of hemoglobin (sO_2) in a blood vessel in vivo presents a challenge in photoacoustic imaging. As a result of wavelength-dependent optical attenuation in the skin, the local fluence at a subcutaneous vessel varies with the optical wavelength in spectral measurement and hence needs to be compensated for so that the intrinsic absorption coefficient can be recovered. Here, by employing a simplified double-layer skin model, we demonstrate that although the absolute value of sO_2 in a vessel is seriously affected by the volume fraction of blood and the spatially averaged sO_2 in the dermis, the difference of sO_2 between neighboring vessels is minimally affected. Experimentally, we acquire compensational factors for the wavelength-dependent optical attenuation by measuring the PA spectrum of a subcutaneously inserted 25 µm thick black film using our PA microscope. We demonstrate in vivo that the difference in sO_2 between a typical artery and a typical vein is conserved before and after spectral compensation. This conservation holds regardless of the animal's systemic physiological state.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1088/0266-5611/23/6/S09DOIArticle
http://iopscience.iop.org/article/10.1088/0266-5611/23/6/S09/metaPublisherArticle
ORCID:
AuthorORCID
Maslov, Konstantin0000-0003-3408-8840
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2007 IOP Publishing Ltd. Received 2 April 2007, in final form 16 October 2007, Published 23 November 2007. This research is sponsored in part by National Institutes of Health grants R01 CA106728 and R01 NS46214 (BRP).
Funders:
Funding AgencyGrant Number
NIHR01 CA106728
NIHR01 NS46214
Issue or Number:6
DOI:10.1088/0266-5611/23/6/S09
Record Number:CaltechAUTHORS:20161005-074721592
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161005-074721592
Official Citation:Konstantin Maslov et al 2007 Inverse Problems 23 S113
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70854
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 Oct 2016 14:53
Last Modified:11 Nov 2021 04:36

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