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Multi-optical-wavelength ultrasound-modulated optical tomography: a phantom study

Kim, Chulhong and Wang, Lihong V. (2007) Multi-optical-wavelength ultrasound-modulated optical tomography: a phantom study. Optics Letters, 32 (16). pp. 2285-2287. ISSN 0146-9592. doi:10.1364/OL.32.002285.

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We used multiple optical wavelengths to study ultrasound-modulated optical tomography (UOT) in tissue phantoms. By using intense acoustic bursts and a CCD camera-based speckle contrast detection technique, we observed variations of the ultrasound-modulated signal at various optical absorptions. The experimental variations were found to be highly correlated with predictions from Monte Carlo simulations. By irradiating the sample at two optical wavelengths, we quantitatively estimated the total concentration and the concentration ratio of double dyes in objects embedded in tissue phantoms. The results suggest that UOT can potentially provide noninvasive functional imaging of the total concentration and oxygen saturation of hemoglobin in biological tissue.

Item Type:Article
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Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2007 Optical Society of America. Received April 12, 2007; revised July 2, 2007; accepted July 6, 2007; posted July 9, 2007 (Doc. ID 82070); published August 2, 2007. We thank H. F. Zhang and R. J. Zemp for fruitful scientific discussions. This research was supported by NIH grants R33 CA 094267 and R01 CA106728.
Funding AgencyGrant Number
NIHR33 CA 094267
NIHR01 CA106728
Issue or Number:16
Classification Code:OCIS codes: 030.1670, 110.6150, 110.7170, 170.6480, 170.3880
Record Number:CaltechAUTHORS:20161005-093141303
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Official Citation:Chulhong Kim and Lihong V. Wang, "Multi-optical-wavelength ultrasound-modulated optical tomography: a phantom study," Opt. Lett. 32, 2285-2287 (2007)
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70869
Deposited By: Tony Diaz
Deposited On:05 Oct 2016 16:40
Last Modified:11 Nov 2021 04:36

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