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Photoacoustic Tomography of a Rat Cerebral Cortex in vivo with Au Nanocages as an Optical Contrast Agent

Yang, Xinmai and Skrabalak, Sara E. and Li, Zhi-Yuan and Xia, Younan and Wang, Lihong V. (2007) Photoacoustic Tomography of a Rat Cerebral Cortex in vivo with Au Nanocages as an Optical Contrast Agent. Nano Letters, 7 (12). pp. 3798-3802. ISSN 1530-6984. http://resolver.caltech.edu/CaltechAUTHORS:20161005-110258933

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Abstract

Poly(ethylene glycol)-coated Au nanocages have been evaluated as a potential near-infrared (NIR) contrast agent for photoacoustic tomography (PAT). Previously, Au nanoshells were found to be an effective NIR contrast agent for PAT; however, Au nanocages with their more compact sizes (<50 nm compared to >100 nm for Au nanoshells) and larger optical absorption cross sections should be better suited for in vivo applications. We sequentially injected Au nanocages into the circulatory system of a rat in three administrations and in vivo PAT was conducted immediately prior to the first injection and continued until 5 h after the final injection. A gradual enhancement of the optical absorption in the cerebral cortex, by up to 81%, was observed over the course of the experiment.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1021/nl072349rDOIArticle
http://pubs.acs.org/doi/abs/10.1021/nl072349rPublisherArticle
http://pubs.acs.org/doi/suppl/10.1021/nl072349rPublisherSupporting Information
ORCID:
AuthorORCID
Wang, Lihong V.0000-0001-9783-4383
Additional Information:© 2007 American Chemical Society. Received September 12, 2007; Revised Manuscript Received November 4, 2007; Publication Date (Web): November 20, 2007. We thank Erich Stein for experimental assistance. This project was supported in part by the National Institutes of Health (NIH) Grants R01 NS46214 and R01 EB000712 (both to L.V.W.), as well as an NIH Director's Pioneer Award (5DP1OD000798) and a National Science Foundation Grant (DMR-0451788) (both to Y.X.). Z.Y.L. thanks the National Natural Science Foundation of China (Nos. 10525419 and 60736041) for financial support.
Funders:
Funding AgencyGrant Number
NIHR01 NS46214
NIHR01 EB000712
NIH5DP1OD000798
NSFDMR-0451788
National Natural Science Foundation of China10525419
National Natural Science Foundation of China60736041
Record Number:CaltechAUTHORS:20161005-110258933
Persistent URL:http://resolver.caltech.edu/CaltechAUTHORS:20161005-110258933
Official Citation:Photoacoustic Tomography of a Rat Cerebral Cortex in vivo with Au Nanocages as an Optical Contrast Agent Xinmai Yang, Sara E. Skrabalak, Zhi-Yuan Li, Younan Xia, and Lihong V. Wang Nano Letters 2007 7 (12), 3798-3802 DOI: 10.1021/nl072349r
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70877
Collection:CaltechAUTHORS
Deposited By: Tony Diaz
Deposited On:05 Oct 2016 18:12
Last Modified:05 Oct 2016 18:12

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