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Organization, Transcription, and Regulation in the Animal Genome

Davidson, Eric H. and Britten, Roy J. (1973) Organization, Transcription, and Regulation in the Animal Genome. Quarterly Review of Biology, 48 (4). pp. 565-613. ISSN 0033-5770.

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This review concern recent experimental information areas of animal cell molecular biology which are relevant to the mechanism of gene regulation. New data regarding interspersion and clustering of repetitive sequence elements in DNA are considered Molecular characteristics of animal structural genes and mRNAs are discussed, with particular reference the frequency of structural gene sequences, mRNA turn over and the interpretation of dipteran complementation groups. The molecular characteristics of nuclear RNAs, the primary transcription products, are reviewed. Evidence for transcription level regulation is summarized and the relation of nuclear and mRNA examined. The protein activator branch of the Britten-Davidson model for gene regulation is further developed and considered in light of current knowledge.

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Additional Information:© 1973 The University of Chicago Press. We gratefully acknowledge the extensive assistance and criticism provided by our colleagues Barbara Hough and William Klein. Extremely valuable critical reviews were provided by Norman Davidson, Lee Hood, Edward Lewis, and Fotis Kafatos. We thank Jane Rigg for her invaluable aid in the preparation of the manuscript. This work was supported in part by USPH grant HD-05753.
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U.S. Public Health Service (USPHS)HD-05753
Issue or Number:4
Record Number:CaltechAUTHORS:20161005-141851183
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Official Citation:Davidson, Eric H., and Roy J. Britten. "Organization, Transcription, and Regulation in the Animal Genome." The Quarterly Review of Biology 48, no. 4 (1973): 565-613.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70884
Deposited By: Ruth Sustaita
Deposited On:05 Oct 2016 22:11
Last Modified:03 Oct 2019 16:02

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