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The crystal structure of a proposed fusidic acid intermediate

Bordner, J. and Stanford, R. H., Jr. and Dickerson, R. E. (1970) The crystal structure of a proposed fusidic acid intermediate. Acta crystallographica. Section B, Structural crystallography and crystal chemistry, 26 (12). pp. 2107-2112. ISSN 0567-7408. https://resolver.caltech.edu/CaltechAUTHORS:20161005-160112068

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Abstract

The structure of a proposed intermediate in the synthesis of the abnormal steroid fusidic acid was determined by means of X-ray analysis. The compound, C_(23)H_(27)O_3Br, forms triclinic crystals, space group P1[bar], with cell dimensions a = 8.681, b = 7.361, c = 16.077 Å, α = 90.85, β = 99.44, γ = 84.97°; there are two molecules in the cell. The structure was refined to an R index of 6.3% for 1979 non-zero reflections measured on a diffractometer. The results of the analysis revealed that the proposed intermediate has a structure incompatible for conversion to the desired steroid.


Item Type:Article
Related URLs:
URLURL TypeDescription
http://dx.doi.org/10.1107/S0567740870005459DOIArticle
http://scripts.iucr.org/cgi-bin/paper?S0567740870005459PublisherArticle
Additional Information:© 1970 International Union of Crystallography. (Received 10 September 1968 and in revised form 4 August 1969) Contribution No. 3708 from the Gates and Crellin Laboratories of Chemistry. This investigation was supported in part by research grants GM 12121 from the United States Public Health Service and GB 6617X from the National Science Foundation.
Funders:
Funding AgencyGrant Number
U.S. Public Health Service (USPHS)GM-12121
NSFGB 6617X
Other Numbering System:
Other Numbering System NameOther Numbering System ID
Gates and Crellin Laboratories of Chemistry3708
Issue or Number:12
Record Number:CaltechAUTHORS:20161005-160112068
Persistent URL:https://resolver.caltech.edu/CaltechAUTHORS:20161005-160112068
Official Citation:Bordner, J., Stanford, R. H. & Dickerson, R. E. (1970). Acta Cryst. B26, 2107-2112.
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70901
Collection:CaltechAUTHORS
Deposited By: George Porter
Deposited On:14 Oct 2016 22:39
Last Modified:03 Oct 2019 16:02

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