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The Crystal Structure of Guanosine Dihydrate and Inosine Dihydrate

Thewalt, Ulf and Bugg, Charles E. and Marsh, Richard E. (1970) The Crystal Structure of Guanosine Dihydrate and Inosine Dihydrate. Acta crystallographica. Section B, Structural crystallography and crystal chemistry, 26 (8). pp. 1089-1101. ISSN 0567-7408.

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Crystals of the dihydrates of guanosine (C_(10)H_(13)N_5O_5) and inosine (C_(10)H_(12)N_4O_5) are nearly isostructural. They are monoclinic, space group P2_1, with cell dimensions ɑ = 17·518, b = 11 ·502, c = 6·658 Å, β = 98·17° (guanosine) and ɑ = 17·573, b =11·278, c=6-654 Å, β = 98·23° (inosine). There are two nucleoside molecules and four water molecules per asymmetric unit. Data were collected on an automated diffractometer; the structures were solved by Patterson and trial-and-error methods and refined to R indices of about 0·035. The structure features hydrogen bonding between purine bases to form ribbons parallel to b and parallel stacking of purine bases along c; the separation between adjacent rings within a stack is 3·3 Å. The conformations about the glycosidic C-N bond and the puckerings of the sugar rings arc quite different for the two molecules in the asymmetric unit.

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Additional Information:© 1970 International Union of Crystallography. Received 14 August 1969. This investigation was supported in part by Research Grant No. HE-02143 from the United States Public Health Service.
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U.S. Public Health Service (USPHS)HE-02143
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Arthur Amos Noyes Laboratory of Chemical Physics3884
Issue or Number:8
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Official Citation:The crystal structure of guanosine dihydrate and inosine dihydrate U. Thewalt, C. E. Bugg and R. E. Marsh Acta Cryst. (1970). B26, 1089-1101 doi: 10.1107/S0567740870003667
Usage Policy:No commercial reproduction, distribution, display or performance rights in this work are provided.
ID Code:70933
Deposited By: Ruth Sustaita
Deposited On:12 Oct 2016 23:05
Last Modified:03 Oct 2019 16:02

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